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Training the Innate Immune System Against SARS-CoV-2 (COVID-19) Using the Shingrix Vaccine in Nursing Home Residents (NH-Shingrix)
The purpose of this study is to measure the effect of the Shingrix vaccine on your immune system and whether that has any effect on the body's ability to fight off other infections such as COVID-19. We hypothesize that: H1: Shingrix vaccination will elevate acute and trained immunity H2: For 6 months following the first injection, increased levels of acute and trained immunity is associated with less disease, including fewer hospitalizations and deaths associated with flu, pneumonia, and COVID-19.
Details
| Lead sponsor | University of Oklahoma |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | COMPLETED |
| Enrolment | 217 |
| Start date | Tue Sep 01 2020 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri May 19 2023 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Herpes Zoster
- Allergy and Immunology
- Corona Virus Infection
Interventions
- SHINGRIX (Zoster Vaccine REcombinant, Adjuvanted)
- Normal Saline
Countries
United States