NCT04515056 is a NA clinical trial of Papain 10 µg in Papain, sponsored by Aalborg University.

Who is sponsoring NCT04515056?

NCT04515056 is sponsored by Aalborg University.

What drugs are being tested in NCT04515056?

Interventions in NCT04515056: Papain 10 µg, Papain 50 µg, Papain 100 µg, Vehicle, Papain 1 SPT, Papain 5 SPT, Papain 25 SPT, Cowhage.

What condition does NCT04515056 study?

NCT04515056 studies Papain, Itch, Skin Prick Test (SPT).

Is NCT04515056 still recruiting?

NCT04515056 is currently completed. Last updated 9 July 2021.

Last reviewed 2021-07-09 · How we verify

NCT04515056

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Characterization of New Human Models of Non-histaminergic Itch

Completed NA Last updated 9 July 2021

What this trial tests

NA trial testing Papain 10 µg in Papain in 20 participants. Completed in 1 June 2021.

Timeline

1 September 2020

Primary endpoint
1 June 2021

1 June 2021

Quick facts

Lead sponsor	Aalborg University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	single
Primary purpose	basic science
Enrollment	20
Start date	1 September 2020
Primary completion	1 June 2021
Estimated completion	1 June 2021
Sites	1 location across Denmark

Drugs / interventions tested

Papain 10 µg — full drug profile →
Papain 50 µg
Papain 100 µg — full drug profile →
Vehicle
Papain 1 SPT — full drug profile →
Papain 5 SPT — full drug profile →
Papain 25 SPT — full drug profile →
Cowhage

Conditions studied

Papain — all drugs for Papain →
Itch — all drugs for Itch →
Skin Prick Test (SPT) — all drugs for Skin Prick Test (SPT) →

Sponsor

Aalborg University

Who can join

Adults 18 to 60, any sex, with Papain or Itch. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In this experiment the investigators would like to test a new new human itch model based on papain, and to characterize the sensory quality and temporary aspects of papain skin prick test (SPT) in comparison to the inactivated-cowhage delivery system.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Physiological functions and pharmacological targeting of transient receptor potential channels.
Chubanov V, Grimm C, Hill K, Schaefer M, et al · · 2025 · PMID 41118703 · DOI 10.1016/j.pharmr.2025.100089

Verify or expand the search:

Other Aalborg University trials

Trials by the same sponsor.

NCT07580989 — Network Effects of Left M1 rTMS: A TMS-EEG Study · NA · recruiting
NCT07395882 — A New Model to Induce Itch and Inflammation · NA · not yet recruiting
NCT07395869 — Off-set Analgesia Induced by Cold Temperature · NA · not yet recruiting
NCT07266103 — Mechanistic Study of Personalized rTMS in Chronic Pain · NA · not yet recruiting
NCT07373392 — Effects of LP-LDL® on Lipid Metabolism, Glycemic Control, Inflammatory Markers, and Cognitive Function in Individuals Wi · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04515056 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Aalborg University
Last refreshed: 9 July 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04515056.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing