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NCT04512638: BETCON
Best Treatment Choice for Osteonecrosis of the Jaw
Phase 4 trial testing Antibiotics in Medication Related Osteonecrosis of the Jaw in 125 participants. Status unknown.
1 October 2025
Quick facts
| Lead sponsor | Tim Van den Wyngaert |
|---|---|
| Phase | Phase 4 |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 125 |
| Start date | 1 January 2021 |
| Primary completion | 1 October 2025 |
| Estimated completion | 1 January 2026 |
| Sites | 4 locations across Belgium |
Drugs / interventions tested
- Antibiotics — full drug profile →
- Chlorhexidine mouthwash — full drug profile →
- Minimally invasive surgery with LPRF
- Surgical resection
Conditions studied
- Medication Related Osteonecrosis of the Jaw — all drugs for Medication Related Osteonecrosis of the Jaw →
Sponsor
Tim Van den Wyngaert
Who can join
18 and older, any sex, with Medication Related Osteonecrosis of the Jaw. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
BETCON is a pragmatic randomized controlled open-label multi-center study in patients with newly diagnosed stage I-II MRONJ designed to answer the question whether minimally invasive management with LPRF membranes or primary surgical treatment is better than the standard of care of conservative therapy alone. The primary end-point is the time to mucosal healing. Secondary end-points consist of supporting measures of efficacy, patient reported symptoms, quality of life, well-being, and functioning.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Interventions for managing medication-related osteonecrosis of the jaw.
Beth-Tasdogan NH, Mayer B, Hussein H, Zolk O, et al · · 2022 · cited 70× · PMID 35866376 · DOI 10.1002/14651858.cd012432.pub3
Verify or expand the search:
- PubMed search for NCT04512638
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04512638 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tim Van den Wyngaert
- Last refreshed: 23 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04512638.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing