NCT04511325

Effects of White Potato Consumption on Measures of Cardiometabolic Health in Individuals With Type 2 Diabetes Mellitus

Completed NA Last updated 8 September 2022

What this trial tests

NA trial testing Potato Regimen in Type2 Diabetes in 27 participants. Completed in 20 May 2022.

Timeline

27 April 2019

Primary endpoint
20 May 2022

20 May 2022

Quick facts

Lead sponsor	Florida State University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	27
Start date	27 April 2019
Primary completion	20 May 2022
Estimated completion	20 May 2022
Sites	1 location across United States

Drugs / interventions tested

• Potato Regimen
• Refined Grain Regimen

Conditions studied

• Type2 Diabetes — all drugs for Type2 Diabetes →
• Cardiometabolic Syndrome — all drugs for Cardiometabolic Syndrome →
• Arterial Stiffness — all drugs for Arterial Stiffness →
• Overweight and Obesity — all drugs for Overweight and Obesity →

Sponsor

Florida State University

Who can join

Adults 45 to 80, any sex, with Type2 Diabetes or Cardiometabolic Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators are examining the effects of potato consumption on indices of glycemic control and cardiovascular health in overweight and obese individuals with type two diabetes mellitus (T2D) to provide feasible and effective dietary ways for individuals to enhance their quality of life. The overall objective of this crossover study is to collect data regarding the effects of potato consumption on indices of glycemic control and cardiovascular health among overweight and obese individuals with T2D. The central hypothesis of this crossover study is that the daily consumption of 100 g white potato for 12 weeks will contribute to improvements in glycemic control, reductions in inflammation, and improvements in blood lipids and vascular function in overweight and obese individuals with T2D compared to a macronutrient-matched refined grain (75 g cooked long-grain white rice) for 12 weeks (with a 2 week washout period between interventions).

Specific Aim) The assessment of blood glucose control, vascular function, body composition and overall cardiovascular risk after consumption of potatoes (100g/d for 12 weeks) in individuals with T2D compared to a calorie matched refined grain at the initial baseline visit as well as the 6-, and 12-week study visits (for each 12-week intervention period).

This aim will assess changed in blood glucose, insulin, HbA1c, HOMA-IR, and HOMA-β as well as the following:

1. blood pressure (BP)
2. markers of endothelial function \[flow-mediated dilation (FMD), pulse wave velocity (PWV), and endothelin-1 (ET-1)\]
3. markers of inflammation (C-reactive protein)
4. body composition via bioelectrical impedance (BIA), lean mass and fat mass assessment
5. lipid profiles, consisting of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and oxidized LDL (Ox-LDL). Atherogenic risk ratios (TC/HDL-C, LDL-C/HDL-C, HDL-C/LDL-C) will also be assessed
6. anthropometrics \[weight, height, waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WC/HC)\]

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The Comparative Effects of White Potato and White Rice Consumption on Measures of Cardiometabolic Health in Individuals with Type 2 Diabetes Mellitus and Features of Metabolic Syndrome.
   Akhavan NS, Clarke HE, Behl TA, Singar S, et al · · 2025 · PMID 40927748 · DOI 10.1016/j.cdnut.2025.107518