NCT04505371 (WISH) is a NA clinical trial of Wellness Intervention for Smokers with HIV in HIV Infections, sponsored by Seattle Institute for Biomedical and Clinical Research.

Who is sponsoring NCT04505371?

NCT04505371 is sponsored by Seattle Institute for Biomedical and Clinical Research.

What drugs are being tested in NCT04505371?

Interventions in NCT04505371: Wellness Intervention for Smokers with HIV.

What condition does NCT04505371 study?

NCT04505371 studies HIV Infections, Smoking, Smoking Cessation.

Is NCT04505371 still recruiting?

NCT04505371 is currently active, enrolled. Last updated 20 October 2025.

Last reviewed 2025-10-20 · How we verify

NCT04505371: WISH

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV

Active, enrolled NA Last updated 20 October 2025

What this trial tests

NA trial testing Wellness Intervention for Smokers with HIV in HIV Infections in 226 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

4 June 2021

Primary endpoint
31 March 2025

28 February 2026

Quick facts

Lead sponsor	Seattle Institute for Biomedical and Clinical Research
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	226
Start date	4 June 2021
Primary completion	31 March 2025
Estimated completion	28 February 2026
Sites	1 location across United States

Drugs / interventions tested

Wellness Intervention for Smokers with HIV

Conditions studied

HIV Infections — all drugs for HIV Infections →
Smoking — all drugs for Smoking →
Smoking Cessation — all drugs for Smoking Cessation →

Sponsor

Seattle Institute for Biomedical and Clinical Research

Who can join

18 and older, any sex, with HIV Infections or Smoking. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This project will compare the effectiveness of an HIV-specific comprehensive wellness intervention designed to have broad appeal to smokers living with HIV to the effectiveness of standard care services that include referral to the National VA Quitline and SmokefreeVET texting program. Participants in both arms will have access to pharmacotherapy available through their Veterans Affairs (VA) healthcare providers.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Design and methods of a randomized trial testing the novel Wellness Intervention for Smokers Living with HIV (WISH).
McClure JB, Catz SL, Chalal C, Ciuffetelli R, et al · · 2021 · cited 5× · PMID 34776121 · DOI 10.1016/j.cct.2021.106486
"I Thought Cancer was a Tobacco Issue": Perspectives of Veterans with and without HIV on Cancer and Other Health Risks Associated with Alcohol and Tobacco/Nicotine Use.
Briggs ES, Thomas RM, Frost MC, Fletcher OV, et al · · 2024 · PMID 38869757 · DOI 10.1007/s10461-024-04363-6

Verify or expand the search:

Other recruiting trials for HIV Infections

Currently open trials in the same condition.

NCT07225530 — Implementation of Screen, Treat, and Triage for Women Living With HIV in La Romana (iSTAR) · NA · recruiting
NCT07202546 — A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study) · Phase 2 · recruiting
NCT06694753 — Safety and Immunogenicity Study of Three mRNAs Encoding HIV Immunogens in Adult Participants Without HIV and in Overall · Phase 1 · recruiting
NCT07235852 — Pilot Testing Into the Feasibility of the Developed Cognitive Behavioral Therapy Intervention · NA · recruiting
NCT06665646 — Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Ad · Phase 1 · recruiting

Other Seattle Institute for Biomedical and Clinical Research trials

Trials by the same sponsor.

NCT06390345 — Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention · NA · recruiting
NCT05473065 — A Prosthetic Foot Test-Drive Strategy for Improving Stability in Veterans With Leg Amputations · NA · recruiting
NCT05776719 — Efficacy of Virtual Warrior Renew Therapy for Veterans Who Experienced Military Sexual Trauma · NA · active not recruiting
NCT05718102 — Pragmatic Trial to Enhance Quality Safety, and Patient Experience in COPD · NA · recruiting
NCT04049331 — Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone · Phase 2 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04505371 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Seattle Institute for Biomedical and Clinical Research
Last refreshed: 20 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04505371.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing