NCT04500275 is a Phase 4 clinical trial of Vancomycin Hydrochloride in Sternal Wound Infection, sponsored by National Cheng-Kung University Hospital.

Who is sponsoring NCT04500275?

NCT04500275 is sponsored by National Cheng-Kung University Hospital.

What drugs are being tested in NCT04500275?

Interventions in NCT04500275: Vancomycin Hydrochloride, Normal Saline.

What condition does NCT04500275 study?

NCT04500275 studies Sternal Wound Infection.

Is NCT04500275 still recruiting?

NCT04500275 is currently completed. Last updated 8 April 2025.

Last reviewed 2025-04-08 · How we verify

NCT04500275

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Topical Vancomycin Over Sternal Edge in Cardiac Surgery

Completed Phase 4 Last updated 8 April 2025

What this trial tests

Phase 4 trial testing Vancomycin Hydrochloride in Sternal Wound Infection in 360 participants. Completed in 31 March 2025.

Timeline

1 July 2020

Primary endpoint
31 March 2025

31 March 2025

Quick facts

Lead sponsor	National Cheng-Kung University Hospital
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	360
Start date	1 July 2020
Primary completion	31 March 2025
Estimated completion	31 March 2025
Sites	1 location across Taiwan

Drugs / interventions tested

Vancomycin Hydrochloride — full drug profile →
Normal Saline

Conditions studied

Sternal Wound Infection — all drugs for Sternal Wound Infection →

Sponsor

National Cheng-Kung University Hospital

Who can join

20 and older, any sex, with Sternal Wound Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical application of vancomycin paste over sternum edge is safe and can reduce sternal wound infection after elective cardiac surgery. Vancomycin paste will be prepared using 2.5 g of vancomycin mixed with 2 ml normal saline. Vancomycin paste as control or 2 ml normal saline as placebo will be spread on sternal edge immediately after sternotomy and before sternal closure. The safety of Vancomycin paste over sternum edge will be assessed according to postoperative serum Vancomycin exposure and potential side effects such as renal toxicity or bacterial resistance. Effect of topical Vancomycin on incidence of postoperative sternal wound infection will be assessed on postoperative 7, 30, and 90 days.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Interventions to prevent surgical site infection in adults undergoing cardiac surgery.
Cardiothoracic Interdisciplinary Research Network, Rogers LJ, Vaja R, Bleetman D, et al · · 2024 · cited 2× · PMID 39620424 · DOI 10.1002/14651858.cd013332.pub2

Verify or expand the search:

Other trials of Vancomycin Hydrochloride

Trials testing the same drug.

NCT03221023 — Intrawound Vancomycin Prophylaxis for Neural Stimulator · Phase 2, PHASE3 · unknown

Other National Cheng-Kung University Hospital trials

Trials by the same sponsor.

NCT07525713 — Virtual Reality Mirror Therapy With Focused Object-Directed Attention System · NA · not yet recruiting
NCT07369271 — Continuous Cervical Erector Spinae Plane Block Versus Interscalene Nerve Block in Shoulder Arthroscopic Surgery · NA · not yet recruiting
NCT07262411 — Peer-based Recovery Program · NA · not yet recruiting
NCT07257926 — Prevention of Delayed Post-polypectomy Bleeding by Endoscopic Sucralfate Spray in High-risk Patients: A Randomized Contr · Phase 4 · not yet recruiting
NCT07269132 — Applying the ADDIE Model to Develop a Multimedia Program to Enhance Chemotherapy Knowledge and Self-Efficacy Among Inten · NA · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04500275 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Cheng-Kung University Hospital
Last refreshed: 8 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04500275.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing