Who is sponsoring NCT04499664?

NCT04499664 is sponsored by Hvidovre University Hospital.

What drugs are being tested in NCT04499664?

Interventions in NCT04499664: Monitoring of the autonomic nervous system.

What condition does NCT04499664 study?

NCT04499664 studies Autonomic Dysfunction, Autonomic Imbalance, Blood Loss.

Is NCT04499664 still recruiting?

NCT04499664 is currently completed. Last updated 30 August 2022.

Last reviewed 2022-08-30 · How we verify

NCT04499664

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Autonomic Cardiovascular Control in Response to Blood Volume Reduction in Blood Donors

Completed Last updated 30 August 2022

What this trial tests

trial testing Monitoring of the autonomic nervous system in Autonomic Dysfunction in 25 participants. Completed in 1 June 2022.

Timeline

1 August 2020

Primary endpoint
1 September 2020

1 June 2022

Quick facts

Lead sponsor	Hvidovre University Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	25
Start date	1 August 2020
Primary completion	1 September 2020
Estimated completion	1 June 2022
Sites	1 location across Denmark

Drugs / interventions tested

Monitoring of the autonomic nervous system

Conditions studied

Autonomic Dysfunction — all drugs for Autonomic Dysfunction →
Autonomic Imbalance — all drugs for Autonomic Imbalance →
Blood Loss — all drugs for Blood Loss →

Sponsor

Hvidovre University Hospital

Who can join

Adults 30 to 45, male only, with Autonomic Dysfunction or Autonomic Imbalance. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The function of the autonomic nervous system can be assessed using baroreflex sensitivity (BRS) and heart rate variability (HRV). Decreased HRV has been shown to be predictive of morbidity and mortality in diverse medical conditions such as acute myocardial infarction, aneurysmal subarachnoid haemorrhage, autoimmune diseases, sepsis and surgery. The function of the autonomic nervous system has not yet been investigated in a "pure hypovolemia" model. The aim of the current study is therefore to investigate and describe the function of the autonomic nervous system prior to, during and after reduction of blood volume in healthy blood donors.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Orthostatic intolerance after acute mild hypovolemia: incidence, pathophysiologic hemodynamics, and heart-rate variability analysis-a prospective observational cohort study.
Hristovska AM, Uldall-Hansen B, Mehlsen J, Andersen LB, et al · · 2023 · cited 3× · PMID 37752379 · DOI 10.1007/s12630-023-02556-6

Verify or expand the search:

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Other Hvidovre University Hospital trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04499664 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hvidovre University Hospital
Last refreshed: 30 August 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04499664.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing