NCT04496687

International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry

Recruiting now Last updated 17 December 2024

What this trial tests

trial in Spontaneous Coronary Artery Dissection in 1,000 participants. Currently enrolling.

Timeline

8 March 2019

Primary endpoint
31 December 2025

31 December 2025

Quick facts

Lead sponsor	SCAD Alliance
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	1,000
Start date	8 March 2019
Primary completion	31 December 2025
Estimated completion	31 December 2025
Sites	31 locations across United States, Australia

Conditions studied

• Spontaneous Coronary Artery Dissection — all drugs for Spontaneous Coronary Artery Dissection →

Sponsor

SCAD Alliance

Who can join

18 and older, any sex, with Spontaneous Coronary Artery Dissection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD.

The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its recurrence. This observational study will be prospective and retrospective in its recruitment and will collect clinical information to better understand the natural history and prognosis for SCAD.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Revascularization in Patients With Spontaneous Coronary Artery Dissection: Where Are We Now?
   Krittanawong C, Gulati R, Eitzman D, Jneid H. · · 2021 · cited 28× · PMID 34187166 · DOI 10.1161/jaha.120.018551
2. Posttraumatic Stress Disorder After Spontaneous Coronary Artery Dissection: A Report of the International Spontaneous Coronary Artery Dissection Registry.
   Sumner JA, Kim ESH, Wood MJ, Chi G, et al · · 2024 · cited 16× · PMID 38533943 · DOI 10.1161/jaha.123.032819
3. Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: <i>JACC</i> Advances Expert Panel.
   Crousillat D, Sarma A, Wood M, Naderi S, et al · · 2024 · cited 11× · PMID 39635541 · DOI 10.1016/j.jacadv.2024.101385
4. Spontaneous coronary artery dissection: dissecting an underdiagnosed problem.
   Kalkman DN, Vink AS, Beijk MAM, van den Born BH, et al · · 2025 · cited 2× · PMID 41148429 · DOI 10.1007/s12471-025-01992-x
5. Persistent Left Ventricular Dysfunction After Spontaneous Coronary Artery Dissection: A Report of the iSCAD Registry.
   Henkin S, Wood MJ, Naderi S, Gornik HL, et al · · 2025 · cited 2× · PMID 40482469 · DOI 10.1016/j.jacadv.2025.101854
6. Patient characteristics and incidence of in-hospital events in spontaneous coronary artery dissection and suspected concurrent Takotsubo syndrome: A report of the iSCAD registry.
   Chi G, Kim ESH, Gornik HL, Grodzinsky A, et al · · 2026 · PMID 42199296 · DOI 10.1016/j.ahjo.2026.100793
7. Patient characteristics and incidence of in-hospital events in spontaneous coronary artery dissection and suspected concurrent Takotsubo syndrome: A report of the iSCAD registry
   Chi G, Kim E, Gornik H, Grodzinsky A, et al · · 2026
8. Spontaneous coronary artery dissection in regions of non-Western populations: a systematic literature search and scoping review.
   Kaddoura R, Ahmed A, Al-Hijji M, Cader FA, et al · · 2025 · PMID 40224512 · DOI 10.1093/ehjopen/oeaf022