NCT04496388

The Effect of Different Types of Exercise on Insulin Resistance and Visceral Adipose Tissue in Community Residents.

Completed NA Last updated 4 March 2021

What this trial tests

NA trial testing exercise in Exercise, Insulin Resistance, Visceral Adipose Tissue in 72 participants. Completed in 31 December 2020.

Timeline

7 April 2020

Primary endpoint
31 October 2020

31 December 2020

Quick facts

Lead sponsor	National Taiwan University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	72
Start date	7 April 2020
Primary completion	31 October 2020
Estimated completion	31 December 2020
Sites	1 location across Taiwan

Drugs / interventions tested

• exercise
• No exercise intervention

Conditions studied

• Exercise, Insulin Resistance, Visceral Adipose Tissue — all drugs for Exercise, Insulin Resistance, Visceral Adipose Tissue →

Sponsor

National Taiwan University

Who can join

Adults 40 to 70, any sex, with Exercise, Insulin Resistance, Visceral Adipose Tissue. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background: Exercise has been proven to effectively reduce incidence of diabetes mellitus and metabolic syndrome. However, there is controversial data from prior studies to inform the type of exercise training recommendations.

Aim: The aim of this study will determine the differences of different type of exercise in the effects of reducing insulin resistance and visceral adipose tissue for community residents.

Methods: The four-arm randomized controlled trial will conducted in adults aged 40 to 70 years old in Tainan. A total of at least 177 patients will randomly assign to the group of aerobic exercise (AE), aerobic exercise combined with resistance exercise (RE), AE combined with medium intensity interval training, and placebo. The participants in exercise group will received 12 weeks, 3 times per week program, including twice a week intervention guided by the intervenors, and once a week exercise guided by the video at home. All the exercise keeps moderate-intensity by monitoring with 64%-75% of the maximum heart rate. Insulin resistance status will be checked by HOMA index at baseline and at exercise intervention after 12 weeks (HOMA index= insulin μU/mL）× glucose（mmol/L）/22.5).

Relevance to clinical practice: The research findings will help the clinical health works to know which type of exercise is the best choice in reducing insulin resistance and visceral adipose tissue in community residents, and can be promoted to the general public to reduce the prevalence of metabolic syndrome as well as prevent the root causes of ill health.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Feasibility of Different Exercise Modalities for Community-Dwelling Residents With Physical Inactivity: A Randomized Controlled Trial.
   Chang YH, Shun SC, Chen MH, Chang YF. · · 2023 · cited 3× · PMID 37883059 · DOI 10.1097/jnr.0000000000000578