NCT04493476

Using a Herbal Remedy Extract for the Treatment of Endometriosis Symptoms

Completed Phase 2 Last updated 26 June 2025

What this trial tests

Phase 2 trial testing Chinese herbal formula in Endometriosis in 54 participants. Completed in 1 August 2023.

Timeline

1 October 2020

Primary endpoint
1 May 2023

1 August 2023

Quick facts

Lead sponsor	Carmel Medical Center
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	54
Start date	1 October 2020
Primary completion	1 May 2023
Estimated completion	1 August 2023
Sites	1 location across Israel

Drugs / interventions tested

• Chinese herbal formula

Conditions studied

• Endometriosis — all drugs for Endometriosis →

Sponsor

Carmel Medical Center

Who can join

Adults 18 to 45, female only, with Endometriosis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A prospective, double-blind, placebo-controlled trial examining the effect of Chinese herbal medicine combined with curcumin defined as a dietary supplement on a study group of women with endometriosis, compared to control group.

research product:Chinese herbal extract and curcumin extract, which appear as nutritional supplements in the Ministry of Health database, the research product is packed in 800mg capsules.

Intended use: Composition of 14 different nutritional supplements, in Chinese herbal formula, for the treatment of endometriosis and its symptoms. The formula is formulated according to Chinese medicine principles and aims to reduce inflammation of the pelvic organs and reduce the levels of pain caused by endometriosis disease.

Objectives:Examine the Effect of Using Nutritional Supplements on Symptoms in Patients with Targeted Endometriosis Symptoms.

Primary Endpoints:

Benefit of pain in women suffering from symptoms of endometriosis patients taking herbal extract for 4 months of treatment.

Structure of the study:A prospective, double-blind, double-blind, placebo-controlled (randomized) placebo-controlled trial involving women suffering from endometriosis symptoms and meeting the inclusion and exclusion criteria and who agreed to participate in the study. The women will be randomly divided into the following two arms:

1. Study Group - Taking a daily dose of dietary supplement extract capsules
2. Control group - take a daily dose of Invo capsules Treatment efficacy will be measured according to a dedicated patient questionnaire with endometriosis symptoms that assess quality of life measures.

The study population will include 60 symptomatic women treated at the Multidisciplinary Center for Endometriosis Therapy at Lynn Medical Center.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Copper in Gynecological Diseases.
   Conforti RA, Delsouc MB, Zorychta E, Telleria CM, et al · · 2023 · cited 14× · PMID 38139406 · DOI 10.3390/ijms242417578