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NCT04489758
4DX for the Diagnosis of Constrictive Bronchiolitis
NA trial testing X-ray velocimetry analyzed by 4Dx XV Ventilation Analysis in Constrictive Bronchiolitis in 18 participants. Completed in 27 May 2022.
27 May 2022
Quick facts
| Lead sponsor | Vanderbilt University Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 18 |
| Start date | 25 June 2021 |
| Primary completion | 27 May 2022 |
| Estimated completion | 27 May 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- X-ray velocimetry analyzed by 4Dx XV Ventilation Analysis
Conditions studied
- Constrictive Bronchiolitis — all drugs for Constrictive Bronchiolitis →
Sponsor
Vanderbilt University Medical Center
Who can join
Adults 18 to 60, any sex, with Constrictive Bronchiolitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Constrictive bronchiolitis is an uncommon lung disease that has been described in Veterans of conflicts in Iraq and Afghanistan. Although these Veterans have evidence of constrictive bronchiolitis on lung biopsies, non-invasive tests such as pulmonary function tests (PFTs) are often normal. This study will determine whether analysis of fluoroscopy images using the 4Dx XV Ventilation Analysis software developed by 4D Medical will be able to detect constrictive bronchiolitis in Veterans better than PFTs.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
X-ray velocimetry provides temporally and spatially-resolved biomarkers of lung ventilation in small airways disease.
Richmond BW, Lester MG, Lui V, Dusting J, et al · · 2025 · cited 2× · PMID 40604808 · DOI 10.1186/s12931-025-03295-6
Verify or expand the search:
- PubMed search for NCT04489758
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04489758 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vanderbilt University Medical Center
- Last refreshed: 30 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04489758.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing