NCT04486859 (PIT-CD) is a NA clinical trial of LMWH/Rivaroxaban in Cushing Disease, sponsored by Huashan Hospital.

Who is sponsoring NCT04486859?

NCT04486859 is sponsored by Huashan Hospital.

What drugs are being tested in NCT04486859?

Interventions in NCT04486859: LMWH/Rivaroxaban, IPC.

What condition does NCT04486859 study?

NCT04486859 studies Cushing Disease, DVT, Pulmonary Embolism.

Is NCT04486859 still recruiting?

NCT04486859 is currently active, enrolled. Last updated 2 July 2025.

Last reviewed 2025-07-02 · How we verify

NCT04486859: PIT-CD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Postoperative Thrombosis Prevention in Patients With CD

Active, enrolled NA Last updated 2 July 2025

What this trial tests

NA trial testing LMWH/Rivaroxaban in Cushing Disease in 206 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 December 2020

Primary endpoint
1 May 2025

1 July 2025

Quick facts

Lead sponsor	Huashan Hospital
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	206
Start date	1 December 2020
Primary completion	1 May 2025
Estimated completion	1 July 2025
Sites	7 locations across China

Drugs / interventions tested

LMWH/Rivaroxaban — full drug profile →
IPC

Conditions studied

Cushing Disease — all drugs for Cushing Disease →
DVT — all drugs for DVT →
Pulmonary Embolism — all drugs for Pulmonary Embolism →

Sponsor

Huashan Hospital

Who can join

Adults 18 to 65, any sex, with Cushing Disease or DVT. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Patients with Cushing disease was randomized to 2 groups. After surgery, the patients were managed with mechanical prevention or mechanical prevention plus anticoagulant drugs(LMWH followed by rivaroxaban), VTE was observed 24h, 5day, 4weeks and 12weeks after surgery.Bleeding events were also recorded.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Significant Variability in Postoperative Thromboprophylaxis in Cushing's Disease Patients: A Survey of the North American Skull Base Society and the AANS/CNS Joint Tumor Section.
White AJ, Almeida JP, Petitt JC, Yogi-Morren D, et al · · 2024 · cited 3× · PMID 39228887 · DOI 10.1055/s-0043-1772698
Postoperative Initiation of Thromboprophylaxis in patients with Cushing's Disease (PIT-CD): a randomized controlled trial.
Qiao N, He M, Ye Z, Gong W, et al · · 2025 · PMID 40544300 · DOI 10.1186/s13063-025-08923-6

Verify or expand the search:

Other recruiting trials for Cushing Disease

Currently open trials in the same condition.

NCT07463625 — Evaluation of Positron Emission Tomography (PET) With [18F]FET for the Detection of ACTH-Secreting Corticotroph Pituitar · recruiting
NCT03831958 — Long-Term Follow-Up of Survivors of Pediatric Cushing Disease · recruiting
NCT03364803 — Collecting Information About Treatment Results for Patients With Cushing's Syndrome · recruiting
NCT00001595 — An Investigation of Pituitary Tumors and Related Hypothalmic Disorders · recruiting

Other Huashan Hospital trials

Trials by the same sponsor.

NCT07469735 — Vorasidenib Guided by AGX PET in Recurrent/Low-grade Glioma · NA · not yet recruiting
NCT07364487 — This is an Open-Label Study to Assess the Safety and Efficacy of GC012F in Patients With Multiple Sclerosis · EARLY_PHASE1 · withdrawn
NCT07369830 — The Impact of Probiotic Intervention on the Gut Microbiota and Bowel Function · NA · recruiting
NCT07185373 — Orelabrutinib Combined With Teniposide, Rituximab and Methotrexate for Newly Diagnosed PCNSL · Phase 2, PHASE3 · not yet recruiting
NCT07075029 — RSV in Acute Respiratory Infection Surveillance Among Community-Dwelling Elderly Aged ≥50 Years in China · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04486859 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Huashan Hospital
Last refreshed: 2 July 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04486859.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing