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Genetic Identification of Monogenic Disorders in Early-onset Stroke Using Targeted Next Generation Sequencing Panel (MDEOS)
The study was designed as a multicenter multiracial prospective observational study of acute ischemic stroke and TIA patients across china. The purpose of this study is to determine the monogenic disorders incidence of Chinese early-onset stroke patients. We plan to consecutively enroll more than 500 patients with early-onset stroke(in the 18- to 45-year age range) admitted in stroke units within 7 days after symptoms onset in participating centers. These early-onset stroke patients are referred for targeted sequencing using 'cerebrovascular disease panel'. By analyzing the sequencing results, we intend to identify monogenic causes causing early-onset stroke and develop clinical algorithms that might assist the clinician in deciding in which early-onset stroke patients testing for monogenic causes of stroke.
Details
| Lead sponsor | Beijing Tiantan Hospital |
|---|---|
| Status | COMPLETED |
| Enrolment | 502 |
| Start date | Fri Aug 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri May 22 2020 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Stroke, Acute
- Transient Ischemic Attack
- Single-gene Disorders
Countries
China