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NCT04482491
Histological Prediction and Choice of the Resection Strategy in Front of a Colorectal Lesion > 2 cm: Prospective Comparison of Endoscopic Characterization, Non-targeted and Targeted Biopsies
trial testing Endoscopic Submucosal Dissection in Endoscopic Submucosal Dissection in 90 participants. Completed in 1 January 2020.
1 January 2019
Quick facts
| Lead sponsor | Hôpital Edouard Herriot |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 90 |
| Start date | 1 January 2019 |
| Primary completion | 1 January 2019 |
| Estimated completion | 1 January 2020 |
| Sites | 1 location across France |
Drugs / interventions tested
- Endoscopic Submucosal Dissection
Conditions studied
- Endoscopic Submucosal Dissection — all drugs for Endoscopic Submucosal Dissection →
Sponsor
Hôpital Edouard Herriot
Who can join
Adults 18 to 90, any sex, with Endoscopic Submucosal Dissection. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Colorectal cancer has become a public health priority considering its increased prevalence and high mortality rate when diagnosed late. As a consequence, many countries have promoted and uptaken of colorectal cancer screening programs leading to an increasing detection of advanced but also superficial lesions ESGE (European Society of Gastrointestinal Endoscopy) guidelines states that the majority of those colonic and rectal superficial lesions can be removed in a curative way by standard polypectomy and/or by EMR (Endoscopic Mucosal Resection) and that ESD (Endoscopic Submucosal Dissection) can be considered for removal of colonic and rectal lesions with high suspicion of limited submucosal invasion. Histologically, a resection is curative for the patient when the adenocarcinoma is well-differentiated (G1/G2), with a depth of invasion ≤ sm1 (≤ 1 mm submucosal invasion), with no lymphovascular invasion nor budding and with lateral and deep margins free of cancer
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Histological prediction and choice of the best resection strategy in front of a colorectal lesion > 2 cm: prospective comparison of endoscopic characterization, non-targeted and targeted biopsies.
Lafeuille P, Daire E, Rivory J, Rostain F, et al · · 2025 · PMID 39775045 · DOI 10.1007/s00464-024-11501-7
Verify or expand the search:
- PubMed search for NCT04482491
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Endoscopic Submucosal Dissection
Trials testing the same drug.
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- NCT06159634 — Traction vs. No Traction in Colonic ESD · NA · recruiting
- NCT05736705 — Monopolar and Bipolar in Esophageal ESD · NA · withdrawn
- NCT04919824 — Monopolar Current Cutting Knife vs Bipolar RFA Knife · NA · active not recruiting
- NCT05930860 — Efficacy and Safety of ESD for the Treatment of Superficial Gastric Neoplasms · recruiting
Other recruiting trials for Endoscopic Submucosal Dissection
Currently open trials in the same condition.
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- NCT06748352 — Safety and Efficacy of Traction Robot-assisted Endoscopic Submucosal Dissection for Early Gastric Cancer · NA · recruiting
- NCT06611176 — Local LevoBupivacaine for Pain Relief After Endoscopic Submucosal Dissection for Esophageal Lesions · NA · recruiting
- NCT06476678 — Novel Bipolar Radiofrequency Ablation Knife in Esophageal Lesions · recruiting
- NCT05323929 — The Relationship Between Scar Formation and ESD Depth in Therapy for Gastric Carcinoma · NA · recruiting
Other Hôpital Edouard Herriot trials
Trials by the same sponsor.
- NCT04048447 — Endoscopic Characterization of Colorectal Neoplasia With the Different Published Classifications · completed
- NCT02738359 — Efficacy of Colonoscopy, Colon Capsule and Fecal Immunological Test for Colorectal Cancer Screening · completed
- NCT03205774 — Positioning and Ultrasound Examination of the Gastric Antrum · NA · completed
- NCT03205592 — Ultrasound Assessment of Residual Gastric Content in Critically Ill Patients · completed
- NCT04223947 — Endoscopic Characterization of Colorectal Neoplasia With the Different Published Classifications: a Prospective Comparat · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04482491 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hôpital Edouard Herriot
- Last refreshed: 22 July 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04482491.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing