NCT04480879 is a Phase 1 clinical trial of AZD8154 nebuliser in Asthma, sponsored by AstraZeneca.

Who is sponsoring NCT04480879?

NCT04480879 is sponsored by AstraZeneca.

What drugs are being tested in NCT04480879?

Interventions in NCT04480879: AZD8154 nebuliser, AZD8154 Monodose DPI presented in capsules, AZD8154 Placebo Monodose DPI presented in capsules.

Is NCT04480879 still recruiting?

NCT04480879 is currently terminated. Last updated 24 August 2021.

Last reviewed 2021-08-24 · How we verify

NCT04480879

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of AZD8154 Concentrations in Blood

Terminated Phase 1 Last updated 24 August 2021

What this trial tests

Phase 1 trial testing AZD8154 nebuliser in Asthma in 10 participants. Terminated before completion.

Timeline

17 July 2020

Primary endpoint
2 September 2020

2 September 2020

Quick facts

Lead sponsor	AstraZeneca
Phase	Phase 1
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	10
Start date	17 July 2020
Primary completion	2 September 2020
Estimated completion	2 September 2020
Sites	1 location across Germany

Drugs / interventions tested

AZD8154 nebuliser — full drug profile →
AZD8154 Monodose DPI presented in capsules — full drug profile →
AZD8154 Placebo Monodose DPI presented in capsules

Conditions studied

Asthma — all drugs for Asthma →

Sponsor

AstraZeneca — full company profile →

Who can join

Adults 18 to 55, any sex, with Asthma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is intended to evaluate the systemic pharmacokinetic (PK) characteristics and the safety of AZD8154 following administration of the Monodose DPI formulation compared with the administration of the nebuliser suspension.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases.
Sala V, Della Sala A, Ghigo A, Hirsch E. · · 2021 · cited 20× · PMID 33821232 · DOI 10.15698/cst2021.04.246

Verify or expand the search:

Other recruiting trials for Asthma

Currently open trials in the same condition.

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NCT07282886 — VENTURI (VENTilation Using Respiratory Imaging) · Phase 2 · recruiting
NCT07433569 — A Study to Investigate How Budesonide and Formoterol Move Through the Body (Pharmacokinetics) When Delivered With Differ · Phase 1 · recruiting

Other AstraZeneca trials

Trials by the same sponsor.

NCT06998095 — Tezepelumab (Tezspire) Regulatory Postmarketing Surveillance in Korea · not yet recruiting
NCT07431775 — Saphnelo Use in Females of Child-bearing Potential · not yet recruiting
NCT07516184 — Explore the Diagnostic Value of Bronchodilation Test With Portable Oscillometry in Asthma Diagnosis · NA · not yet recruiting
NCT07279935 — Osimertinib Combined With Chemotherapy in Patients Who Had Distant Recurrence After Adjuvant Osimertinib for EGFRm Resec · Phase 4 · not yet recruiting
NCT07279948 — A Single-arm Observational Study to Characterize the Demographic, Clinical Features and Outcomes of a Brazilian Cohort o · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04480879 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by AstraZeneca
Last refreshed: 24 August 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04480879.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing