Who is sponsoring HUNTIAM?

HUNTIAM is sponsored by Fundación Pública Andaluza para la gestión de la Investigación en Sevilla.

What condition does HUNTIAM study?

HUNTIAM studies Huntington Disease.

What drugs are being tested in HUNTIAM?

Interventions: Moderate doses of Thiamine y Biotin, High doses of Thiamine y Biotin.

What is the status of HUNTIAM?

HUNTIAM is currently RECRUITING.

Last reviewed 2025-02-25 · How we verify

Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease (HUNTIAM)

NCT04478734 PHASE2 RECRUITING

Evaluate the safety and tolerability of combined oral thiamine with biotin therapy in patients with Huntington´s disease in mild to moderate stages and it is intended to evaluate the biological effect of the treatment in the central nervous system of these patients using as the main biomarker the increase in the level of thiamine monophosphate (TMP) in cerebrospinal fluid (CSF) of these patients with Huntington Disease (HD) during a follow-up period of one year. Our main hypothesis is that combined thiamine-biotin oral therapy is a secure and well-tolerated treatment, potentially capable of modifying the disease course or avoiding the progression of symptoms in early-stages HD patients

Details

Lead sponsor	Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Phase	PHASE2
Status	RECRUITING
Enrolment	24
Start date	Wed Apr 12 2023 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Tue Dec 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Huntington Disease

Interventions

Moderate doses of Thiamine y Biotin
High doses of Thiamine y Biotin

Countries

Spain