NCT04474431: VEGFluid

Correlation of VEGF-A and Fluid Balance in Septic Shock

Completed NA Last updated 6 February 2026

What this trial tests

NA trial testing Evaluation of VEGF-A levels in patients with septic shock is positively correlated with a positive fluid balance. in Septic Shock in 103 participants. Completed in 17 October 2023.

Timeline

24 December 2019

Primary endpoint
17 October 2023

17 October 2023

Quick facts

Lead sponsor	University Hospital, Rouen
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	103
Start date	24 December 2019
Primary completion	17 October 2023
Estimated completion	17 October 2023
Sites	1 location across France

Drugs / interventions tested

• Evaluation of VEGF-A levels in patients with septic shock is positively correlated with a positive fluid balance.

Conditions studied

• Septic Shock — all drugs for Septic Shock →

Sponsor

University Hospital, Rouen

Who can join

18 and older, any sex, with Septic Shock. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

VEGF is a key molecule in the control of vascular permeability via interactions with the VEGF-receptor on the endothelial cell. Several authors reported plasma VEGF levels are elevated in sepsis shock and associated with increased mortality (1,2).

In septic shock, the main elements of treatment are intravenous fluids, appropriate antibiotics and vasopressors. Some authors observed positive fluid balance is associated with increased mortality rates in patients (3,4).

To the best of our knowledge, no studies have shown a correlation between VEGF levels and the fluid balance. The aim of our study was to determine the role of VEGF in capillary leakage and the positive fluid balance in septic shock.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.