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NCT04473599
Stay Well at Home: a Text-messaging Study Social Distancing
NA trial testing Uniform random message delivery in Depressive Symptoms in 1,000 participants. Completed in 10 January 2023.
25 July 2022
Quick facts
| Lead sponsor | University of California, Berkeley |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 1,000 |
| Start date | 17 April 2020 |
| Primary completion | 25 July 2022 |
| Estimated completion | 10 January 2023 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Uniform random message delivery
- Reinforcement learning message delivery
- Mood ratings only
Conditions studied
- Depressive Symptoms — all drugs for Depressive Symptoms →
- Anxiety — all drugs for Anxiety →
- COVID-19 — all drugs for COVID-19 →
Sponsor
University of California, Berkeley
Who can join
18 and older, any sex, with Depressive Symptoms or Anxiety. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators have developed supportive text-messages in English and Spanish to help people cope with the stress and anxiety of COVID-19 social distancing. The purpose of this study is to examine if automated text-messages will improve depression and anxiety symptoms and enhance positive mood. Additionally, the investigators will compare the effectiveness of sending messages on a random schedule (using a micro-randomized trial design) or sent by a reinforcement learning policy on overall change in depression and anxiety symptoms and daily mood during the 8-week study.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
A Text Messaging Intervention (StayWell at Home) to Counteract Depression and Anxiety During COVID-19 Social Distancing: Pre-Post Study.
Aguilera A, Hernandez-Ramos R, Haro-Ramos AY, Boone CE, et al · · 2021 · cited 16× · PMID 34543230 · DOI 10.2196/25298 -
Effectiveness and implementation of a text messaging intervention to reduce depression and anxiety symptoms among Latinx and Non-Latinx white users during the COVID-19 pandemic.
Haro-Ramos AY, Rodriguez HP, Aguilera A. · · 2023 · cited 9× · PMID 37146444 · DOI 10.1016/j.brat.2023.104318 -
A Text Messaging Intervention for Coping With Social Distancing During COVID-19 (StayWell at Home): Protocol for a Randomized Controlled Trial.
Figueroa CA, Hernandez-Ramos R, Boone CE, Gómez-Pathak L, et al · · 2021 · cited 9× · PMID 33370721 · DOI 10.2196/23592 -
Personalizing a mental health texting intervention using reinforcement learning.
Arévalo Avalos MR, Rosales K, Karr C, Figueroa CA, et al · · 2025 · PMID 41331095 · DOI 10.1038/s44184-025-00173-3
Verify or expand the search:
- PubMed search for NCT04473599
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04473599 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of California, Berkeley
- Last refreshed: 23 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04473599.
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