NCT04472351 is a NA clinical trial of ASCEND-I in Executive Dysfunction, sponsored by Weill Medical College of Cornell University.

Who is sponsoring NCT04472351?

NCT04472351 is sponsored by Weill Medical College of Cornell University.

What drugs are being tested in NCT04472351?

Interventions in NCT04472351: ASCEND-I.

What condition does NCT04472351 study?

NCT04472351 studies Executive Dysfunction, Cognitive Impairment.

Is NCT04472351 still recruiting?

NCT04472351 is currently terminated. Last updated 29 January 2025.

Last reviewed 2025-01-29 · How we verify

NCT04472351

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cognitive Training in Stroke Rehabilitation

Terminated NA Last updated 29 January 2025

What this trial tests

NA trial testing ASCEND-I in Executive Dysfunction in 27 participants. Terminated before completion.

Timeline

12 January 2021

Primary endpoint
15 September 2022

15 September 2022

Quick facts

Lead sponsor	Weill Medical College of Cornell University
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	27
Start date	12 January 2021
Primary completion	15 September 2022
Estimated completion	15 September 2022
Sites	1 location across United States

Drugs / interventions tested

ASCEND-I

Conditions studied

Executive Dysfunction — all drugs for Executive Dysfunction →
Cognitive Impairment — all drugs for Cognitive Impairment →

Sponsor

Weill Medical College of Cornell University

Who can join

Adults 30 to 89, any sex, with Executive Dysfunction or Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a randomized, controlled pilot study to evaluate the efficacy of "ASCEND-I" (A Strategy and Computer-based intervention to ENhance Daily cognitive functioning after stroke - Inpatient), an inpatient intervention that combines computer-based cognitive training and coaching of cognitive strategies to improve working memory (WM) and related executive functions in individuals with stroke. The investigators hypothesize that relative to an "enhanced usual care" control condition, ASCEND will be associated with improvements in WM. The investigators also hypothesize that measures of baseline brain connectivity (assessed via participants' routine clinical magnetic resonance imaging scans) will predict response to ASCEND-I.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Occupational therapy for cognitive impairment in stroke patients.
Gibson E, Koh CL, Eames S, Bennett S, et al · · 2022 · cited 29× · PMID 35349186 · DOI 10.1002/14651858.cd006430.pub3
Reversing the Ruin: Rehabilitation, Recovery, and Restoration After Stroke.
Stockbridge MD, Bunker LD, Hillis AE. · · 2022 · cited 6× · PMID 36181577 · DOI 10.1007/s11910-022-01231-5

Verify or expand the search:

Other recruiting trials for Executive Dysfunction

Currently open trials in the same condition.

NCT06608966 — Epilepsy Journey-An Executive Functioning Intervention for Teens With Epilepsy · NA · recruiting
NCT06267430 — Learning by Heart: The Effectiveness of an EF Training Program for Pre-schoolers With a Severe CHD · NA · recruiting
NCT06447909 — Randomized Controlled Trial of a Behavioral Training App · NA · recruiting
NCT05874791 — Executive Control Training for Adolescents With ADHD: A Randomized Controlled Effectiveness Trial · NA · active not recruiting
NCT05726721 — Profiling the Dynamic of Binge Eating Disorder (PRODY-BED) · recruiting

Other Weill Medical College of Cornell University trials

Trials by the same sponsor.

NCT07485712 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 2 · NA · not yet recruiting
NCT05811338 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1 · NA · not yet recruiting
NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
NCT06818734 — Implementation of a Clinical Decision Support Tool for Postpartum Depression · NA · not yet recruiting
NCT07485725 — Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 3 · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04472351 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Weill Medical College of Cornell University
Last refreshed: 29 January 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04472351.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing