NCT04471701: EPICOVID19

Italian Web-based Cross-sectional Survey on COVID-19

Completed Last updated 7 April 2022

What this trial tests

trial testing Environmental exposure and clinical features in Covid19 in 200,000 participants. Completed in 28 February 2021.

Timeline

13 April 2020

Primary endpoint
28 February 2021

28 February 2021

Quick facts

Lead sponsor	Institute of Biomedical Technologies-National Research Council, Italy
Status	Completed
Study type	OBSERVATIONAL
Enrollment	200,000
Start date	13 April 2020
Primary completion	28 February 2021
Estimated completion	28 February 2021
Sites	1 location across Italy

Drugs / interventions tested

• Environmental exposure and clinical features

Conditions studied

• Covid19 — all drugs for Covid19 →
• SARS-CoV Infection — all drugs for SARS-CoV Infection →
• Survey, Family Life — all drugs for Survey, Family Life →
• Epidemic Disease — all drugs for Epidemic Disease →

Sponsor

Institute of Biomedical Technologies-National Research Council, Italy

Who can join

18 and older, any sex, with Covid19 or SARS-CoV Infection. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that started in late December 2019 in the Hubei province of China caused millions of cases worldwide in just a few months, and evolved into a real pandemic.

However, only approximately 20% of SARS-CoV-2 infected patients required intensive on sub-intensice medical care and the remained experience mild or subclinical form of the disease that did not require hospital admission and a relatively high percentage (40 to 45%) remained asymptomatic.

Understanding the occurrence of SARS-CoV-2-like infectious in a large non-hospitalized population, when the epidemic peak was occurring in Italy, is of paramount importance but data are scarce.

The goal of this research project is to estimate the number of suspected cases of COVID-19 and to investigate the role of the potential factors associated with SARS-CoV-2 infection in a large Italian sample of respondents living in Italy during the lockdown (started in Italy on 9 March 2020).

EPICOVID19 is an Italian countrywide self-administered cross-sectional web-based survey on adult volunteers launched on April 13, 2020.

The on-line questionnaire has been developed starting from the available literature and implemented using an open source platform focusing on beahvioural and clinical features of participants.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey.
   Noale M, Trevisan C, Maggi S, Antonelli Incalzi R, et al · · 2020 · cited 64× · PMID 32842505 · DOI 10.3390/vaccines8030471
2. Self-Reported Symptoms of SARS-CoV-2 Infection in a Nonhospitalized Population in Italy: Cross-Sectional Study of the EPICOVID19 Web-Based Survey.
   Adorni F, Prinelli F, Bianchi F, Giacomelli A, et al · · 2020 · cited 63× · PMID 32650305 · DOI 10.2196/21866
3. Fear of COVID-19 for Individuals and Family Members: Indications from the National Cross-Sectional Study of the EPICOVID19 Web-Based Survey.
   Cori L, Curzio O, Adorni F, Prinelli F, et al · · 2021 · cited 40× · PMID 33801074 · DOI 10.3390/ijerph18063248
4. Association Between Smoking and SARS-CoV-2 Infection: Cross-sectional Study of the EPICOVID19 Internet-Based Survey.
   Prinelli F, Bianchi F, Drago G, Ruggieri S, et al · · 2021 · cited 26× · PMID 33668011 · DOI 10.2196/27091
5. Age-Related Changes in Clinical Presentation of Covid-19: the EPICOVID19 Web-Based Survey.
   Trevisan C, Noale M, Prinelli F, Maggi S, et al · · 2021 · cited 23× · PMID 33579579 · DOI 10.1016/j.ejim.2021.01.028
6. Sex- and gender-related differences linked to SARS-CoV-2 infection among the participants in the web-based EPICOVID19 survey: the hormonal hypothesis.
   Prinelli F, Trevisan C, Noale M, Franchini M, et al · · 2022 · cited 13× · PMID 35241240 · DOI 10.1016/j.maturitas.2021.11.015
7. Epidemiology of SARS-CoV-2 Infection in Italy Using Real-World Data: Methodology and Cohort Description of the Second Phase of Web-Based EPICOVID19 Study.
   Adorni F, Jesuthasan N, Perdixi E, Sojic A, et al · · 2022 · cited 7× · PMID 35162295 · DOI 10.3390/ijerph19031274
8. Missed Opportunities of Flu Vaccination in Italian Target Categories: Insights from the Online EPICOVID 19 Survey.
   Giacomelli A, Galli M, Maggi S, Pagani G, et al · · 2020 · cited 7× · PMID 33182426 · DOI 10.3390/vaccines8040669