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NCT04471402
Determining the Pharmacogenetic Basis of Non-responsiveness to the Sedative Effects of Dexmedetomidine in Children
trial testing Precedex in Pharmacogenetic Study in 100 participants. Status unknown.
31 December 2022
Quick facts
| Lead sponsor | Hong Kong Children's Hospital |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 20 July 2020 |
| Primary completion | 31 December 2022 |
| Estimated completion | 31 December 2022 |
| Sites | 1 location across Hong Kong |
Drugs / interventions tested
- Precedex — full drug profile →
Conditions studied
- Pharmacogenetic Study — all drugs for Pharmacogenetic Study →
- Procedural Anxiety — all drugs for Procedural Anxiety →
- Dexmedetomidine — all drugs for Dexmedetomidine →
Sponsor
Hong Kong Children's Hospital
Who can join
Adults 6 Months to 12, any sex, with Pharmacogenetic Study or Procedural Anxiety. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Intranasal Dexmedetomidine is one of the sedative drugs of choice commonly used as an anxiolytic premedication for children for diagnostic or therapeutic procedures. However, some children do not achieve the level of sedation expected with the usual dose after an expected timeframe, leading to distress and costly time wasted. In this study, we would try to identify a genetic basis to non-responders of Dexmedetomidine by comparing a chosen gene panel of 250 relevant genes between responders and non-responders to a standardized 3mcg/kg intranasal Dexmedetomidine.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04471402
- Europe PMC full search
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Related trials
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Trials testing the same drug.
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- NCT03357718 — Oral Dexmedetomidine vs Midazoam For Premedication · Phase 4 · completed
- NCT02734940 — Multimodal Analgesia in Cardiac Surgery (Pilot Study) · Phase 4 · terminated
- NCT02245256 — Efficacy of Low-dose Dexmedetomidine to Prevent Delirium in Liver Transplant Patients · Phase 4 · completed
Other Hong Kong Children's Hospital trials
Trials by the same sponsor.
- NCT06866873 — CD-19 CAR-T Cell for Pediatric ALL or Lymphoma · NA · recruiting
- NCT07018999 — Immersive Virtual Reality Exposure for Reducing Preoperative Anxiety in Children · NA · completed
- NCT04543968 — Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases · NA · completed
- NCT05754684 — Quadruple Immunotherapy for Neuroblastoma · Phase 2 · recruiting
- NCT04986735 — Prospective Cohort Study of Children With GSD1b Receiving Empagliflozin · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04471402 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hong Kong Children's Hospital
- Last refreshed: 16 March 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04471402.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing