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NCT04466072
Gut Microbiome and Ventricular Arrhythmias
trial testing Stool test for microbial analysis in Ventricular Tachycardia in 30 participants. Status unknown.
31 December 2024
Quick facts
| Lead sponsor | North Florida Foundation for Research and Education |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 30 November 2020 |
| Primary completion | 31 December 2024 |
| Estimated completion | 31 December 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Stool test for microbial analysis
Conditions studied
- Ventricular Tachycardia — all drugs for Ventricular Tachycardia →
- Ventricular Fibrillation — all drugs for Ventricular Fibrillation →
- Gut Microbiome — all drugs for Gut Microbiome →
Sponsor
North Florida Foundation for Research and Education
Who can join
18 and older, any sex, with Ventricular Tachycardia or Ventricular Fibrillation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Ventricular tachycardia and ventricular fibrillation (VT/VF) are the most common causes of sudden cardiac death in patients with diseased hearts. The factors contributing to these deadly arrhythmias are not well understood. The presence of a wide variety of microbial flora in the human GI tract, particularly colon has been well recognized for a long time. There are also emerging links showing the effect of an intact gut microbiome having effects on left ventricular remodeling after myocardial infarction and hypertension. Gut microbiota has also been associated with outcomes in atrial fibrillation. There is little available in current literature showing a relationship between gut microbiome characteristics and ventricular arrhythmia burden. The gut microbiome has particularly strong interactions with neuroendocrine and immunologic mediators and has effects on the modulation of the autonomic nervous system. These systems are also hypothesized to influence ventricular arrhythmias. The investigators propose to study the relation and interaction between gut microbiome and ventricular arrhythmogenesis.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT04466072
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
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Related trials
Other recruiting trials for Ventricular Tachycardia
Currently open trials in the same condition.
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- NCT06360939 — Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease · NA · recruiting
- NCT07116525 — A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter · NA · recruiting
- NCT06891456 — Pulsed Field Ablation for Post-Infarction Ventricular Tachycardia · NA · recruiting
- NCT06592001 — Assessment of a Chronically Implanted Parasternally Delivered EV-ICD Lead (ASCEND EV) Study · NA · active not recruiting
Other North Florida Foundation for Research and Education trials
Trials by the same sponsor.
- NCT04460872 — Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury · Phase 2 · recruiting
- NCT04447365 — The Correlation Between Gut Microbiome-host Interaction and Ventricular Arrhythmias. · unknown
- NCT03923530 — Pressure Assessment to Improve Outcomes After TAVR: a Registry · EARLY_PHASE1 · completed
- NCT03825406 — Prevalence of Wildtype Amyloid After TAVR · withdrawn
- NCT05124990 — Predictive Clinical Diagnosis of Rheumatoid Arthritis Flares Using Non-Invasive Infra-red Thermal Imaging and an AI/ML A · no longer available
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04466072 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by North Florida Foundation for Research and Education
- Last refreshed: 18 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04466072.
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