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NCT04463394
The Hemodynamic Effects of Vasopressin in Patients With Fontan Physiology
EARLY_PHASE1 trial testing Vasopressin in Hypotension in 28 participants. Completed in 15 February 2022.
15 February 2022
Quick facts
| Lead sponsor | Stanford University |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | sequential |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 28 |
| Start date | 12 August 2020 |
| Primary completion | 15 February 2022 |
| Estimated completion | 15 February 2022 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Vasopressin — full drug profile →
Conditions studied
- Hypotension — all drugs for Hypotension →
- Fontan Physiology — all drugs for Fontan Physiology →
Sponsor
Stanford University
Who can join
Eligibility, any sex, with Hypotension or Fontan Physiology. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this study is to evaluate if vasopressin can elevate systemic arterial blood pressures without having a significant effect on pulmonary arterial pressures. Because patients who have undergone Fontan procedures rely on low pressures across the pulmonary vascular bed to maintain cardiac output, vasoactive agents that concomitantly increase systemic and pulmonary pressures may have a deleterious effect in this specific patient population. Hypothesis: In patients with Fontan physiology, vasopressin will increase systemic BP by 20% above baseline, without increasing the transpulmonary gradient.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Acute Hemodynamics in the Fontan Circulation: Open-Label Study of Vasopressin.
Adamson GT, Yu J, Ramamoorthy C, Peng LF, et al · · 2023 · cited 5× · PMID 37462430 · DOI 10.1097/pcc.0000000000003326
Verify or expand the search:
- PubMed search for NCT04463394
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT06329037 — The Effects of Oral Vasopressin on Attention Control: An Eye-tracking Study · NA · recruiting
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Currently open trials in the same condition.
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Other Stanford University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04463394 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Stanford University
- Last refreshed: 14 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04463394.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing