NCT04457349 is a NA clinical trial of Therapeutic Plasma Exchange (TPE) in COVID 19, sponsored by Alexandria University.

Who is sponsoring NCT04457349?

NCT04457349 is sponsored by Alexandria University.

What drugs are being tested in NCT04457349?

Interventions in NCT04457349: Therapeutic Plasma Exchange (TPE).

Is NCT04457349 still recruiting?

NCT04457349 is currently completed. Last updated 15 April 2022.

Last reviewed 2022-04-15 · How we verify

NCT04457349

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Therapeutic Plasma Exchange in Resistant Cytokine Storm of COVID 19

Completed NA Last updated 15 April 2022

What this trial tests

NA trial testing Therapeutic Plasma Exchange (TPE) in COVID 19 in 10 participants. Completed in 20 January 2021.

Timeline

25 July 2020

Primary endpoint
29 December 2020

20 January 2021

Quick facts

Lead sponsor	Alexandria University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	10
Start date	25 July 2020
Primary completion	29 December 2020
Estimated completion	20 January 2021
Sites	1 location across Egypt

Drugs / interventions tested

Therapeutic Plasma Exchange (TPE) — full drug profile →

Conditions studied

COVID 19 — all drugs for COVID 19 →

Sponsor

Alexandria University

Who can join

18 and older, any sex, with COVID 19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This research is planned to illustrate the efficacy of Therapeutic Plasma Exchange (TPE) treatment in COVID-19 patients with resistant cytokine storm state.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Efficacy of Plasmapheresis and Immunoglobulin Replacement Therapy (IVIG) on Patients with COVID-19.
Pourahmad R, Moazzami B, Rezaei N. · · 2020 · cited 34× · PMID 32838178 · DOI 10.1007/s42399-020-00438-2
Proinflammatory Cytokines in Chronic Respiratory Diseases and Their Management.
Chavda VP, Bezbaruah R, Ahmed N, Alom S, et al · · 2025 · cited 14× · PMID 40136649 · DOI 10.3390/cells14060400
Description and Analysis of Cytokine Storm in Registered COVID-19 Clinical Trials: A Systematic Review.
Eljaaly K, Malibary H, Alsulami S, Albanji M, et al · · 2021 · cited 11× · PMID 34199506 · DOI 10.3390/pathogens10060692

Verify or expand the search:

Other recruiting trials for COVID 19

Currently open trials in the same condition.

NCT06871293 — Evaluating the Impact of a Functional and Cognitive Strategy in Patients With Long Covid-19 · NA · recruiting
NCT06599658 — COVID-19 Booster and IIV Schedule in Immunocompromised Hosts · Phase 2 · recruiting
NCT04359836 — A Study to Explore the Role of Gut Flora in COVID-19 Infection · recruiting
NCT04522076 — Prospective Hospital Registry of Patients With Suspected or Confirmed Coronavirus Infection (COVID-19) and Community-acq · active not recruiting
NCT06702540 — Bio-reconfigurable Electronic Platform for Multiplex Detection of Viral Respiratory Pathogens · active not recruiting

Other Alexandria University trials

Trials by the same sponsor.

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NCT07476209 — Sialendoscopy Versus Photobiomodulation in Prevention of Radiation Induced Xerostomia · NA · recruiting
NCT07503626 — Optimization of Orthodontic Bracket Placement by Using Two Different Protocols of Digitally Aided Bonding · NA · recruiting
NCT07522944 — AI-Guided Relaxation for Hemodialysis Anxiety · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04457349 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Alexandria University
Last refreshed: 15 April 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04457349.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing