Who is sponsoring NCT04452305?

NCT04452305 is sponsored by University of Pittsburgh.

What drugs are being tested in NCT04452305?

Interventions in NCT04452305: Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting.

What condition does NCT04452305 study?

NCT04452305 studies Infertility, Male, Cancer, Autoimmune Disorder.

Is NCT04452305 still recruiting?

NCT04452305 is currently recruiting now. Last updated 10 December 2025.

Last reviewed 2025-12-10 · How we verify

NCT04452305

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting

Recruiting now NA Last updated 10 December 2025

What this trial tests

NA trial testing Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting in Infertility, Male in 10 participants. Currently enrolling.

Timeline

10 November 2023

Primary endpoint
1 July 2027

1 July 2028

Quick facts

Lead sponsor	University of Pittsburgh
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	10
Start date	10 November 2023
Primary completion	1 July 2027
Estimated completion	1 July 2028
Sites	1 location across United States

Drugs / interventions tested

Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting

Conditions studied

Infertility, Male — all drugs for Infertility, Male →
Cancer — all drugs for Cancer →
Autoimmune Disorder — all drugs for Autoimmune Disorder →

Sponsor

University of Pittsburgh

Who can join

Eligibility, male only, with Infertility, Male or Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy. The purpose of this study is to test the safety and feasibility of these transplant technologies and restore fertility for these participants.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Effects of clinical medications on male fertility and prospects for stem cell therapy.
Mo P, Zhao Z, Ke X, Fan Y, et al · · 2023 · cited 5× · PMID 37791073 · DOI 10.3389/fcell.2023.1258574
Testicular ageing as a central hallmark of male senescence: characteristics, molecular mechanisms and emerging therapeutic strategies.
Gao J, Wang L, Li W, Liu W. · · 2026 · PMID 41635976 · DOI 10.1080/07853890.2026.2624183
Ultrasound-Guided Rete Testis Approach to Sperm Aspiration and Spermatogonial Stem Cell Transplantation in Patients with Azoospermia
Zielen AC, Peters KA, Shetty G, Gross DA, et al · · 2025 · DOI 10.1101/2025.03.25.25324518

Verify or expand the search:

Other recruiting trials for Infertility, Male

Currently open trials in the same condition.

NCT06950203 — The Effect of Supplementation With Fish Oil (EPAX EVOLVE 05) on Sperm Quality · NA · recruiting
NCT06539585 — Scanning the Meiotic Spindle in Assisted Reproductive Techniques to Assess Oocyte Quality · NA · active not recruiting
NCT05514223 — Measuring Free Radicals in Human Sperm Cells Related to Microbiota and Lifestyle Factors · recruiting
NCT06841861 — Spermatogonial Differentiation Via Testicular Organoid · Phase 1, PHASE2 · recruiting
NCT05903859 — Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI) · Phase 3 · recruiting

Other University of Pittsburgh trials

Trials by the same sponsor.

NCT05601206 — Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE · NA · not yet recruiting
NCT06652815 — Cognition, Metacognition, and Stigma in Patients With Suicidal Ideation · not yet recruiting
NCT06474286 — Prucalopride for Cognitive Functioning in Schizophrenia · NA · not yet recruiting
NCT06488469 — Behavioural Problems and Cognition in Children With Hypoglycemia Unawareness in Type-1 Diabetes Mellitus · NA · not yet recruiting
NCT06652802 — Effectiveness of Nurse-Conducted Brief Intervention (NCBI) Supplemented With Mobile for Preventing Alcohol Use Disorders · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04452305 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Pittsburgh
Last refreshed: 10 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04452305.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing