Who is sponsoring NCT04450810?

NCT04450810 is sponsored by University of Messina.

What drugs are being tested in NCT04450810?

Interventions in NCT04450810: Observation of serum and salivary NLRP3 levels.

What condition does NCT04450810 study?

NCT04450810 studies Metabolic Disease, Periodontal Diseases.

Is NCT04450810 still recruiting?

NCT04450810 is currently completed. Last updated 26 January 2021.

Last reviewed 2021-01-26 · How we verify

NCT04450810

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Role of NLRP3 in Periodontitis and Diabetes

Completed Last updated 26 January 2021

What this trial tests

trial testing Observation of serum and salivary NLRP3 levels in Metabolic Disease in 133 participants. Completed in 30 September 2017.

Timeline

1 June 2014

Primary endpoint
18 September 2017

30 September 2017

Quick facts

Lead sponsor	University of Messina
Status	Completed
Study type	OBSERVATIONAL
Enrollment	133
Start date	1 June 2014
Primary completion	18 September 2017
Estimated completion	30 September 2017
Sites	1 location across Italy

Drugs / interventions tested

Observation of serum and salivary NLRP3 levels

Conditions studied

Metabolic Disease — all drugs for Metabolic Disease →
Periodontal Diseases — all drugs for Periodontal Diseases →

Sponsor

University of Messina

Who can join

Adults 35 to 70, any sex, with Metabolic Disease or Periodontal Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

NLRP3 plays a key role in endothelial function and may be a link for the known interaction of periodontitis and diabetes. The investigators compared the impact of gingival health, periodontitis (CP), diabetes or of both diseases (CP +diabetes) on saliva and serum NLRP3levels.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders.
Ramachandran R, Manan A, Kim J, Choi S. · · 2024 · cited 67× · PMID 38945951 · DOI 10.1038/s12276-024-01261-8
Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases.
Zhao X, Chen X, Zhou Z, Zheng J, et al · · 2025 · cited 1× · PMID 40989572 · DOI 10.1002/mco2.70395

Verify or expand the search:

Other recruiting trials for Metabolic Disease

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Other University of Messina trials

Trials by the same sponsor.

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NCT05122741 — Modulation of Fibrosis-inducing Pathways in Acute Myocardial Infarction · unknown
NCT04994379 — Investigating the Effects of Intensity of Transcranial Direct Current Stimulation on Subjective Appetite · NA · terminated
NCT06787781 — Metabolic and Clinical Effect of Alpha-lipoic Acid Administration in Schizophrenic Subjects · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04450810 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Messina
Last refreshed: 26 January 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04450810.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing