NCT04450134 is a NA clinical trial of Lactose in Exercise Training, sponsored by University Ghent.

Who is sponsoring NCT04450134?

NCT04450134 is sponsored by University Ghent.

What drugs are being tested in NCT04450134?

Interventions in NCT04450134: Lactose, Fexofenadine Hydrochloride, Famotidine, High-intensity interval training (HIIT).

What condition does NCT04450134 study?

NCT04450134 studies Exercise Training, Physical Activity.

Is NCT04450134 still recruiting?

NCT04450134 is currently completed. Last updated 7 June 2024.

Last reviewed 2024-06-07 · How we verify

NCT04450134

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Histamine H1/H2 Receptors and Training Adaptations

Completed NA Last updated 7 June 2024

What this trial tests

NA trial testing Lactose in Exercise Training in 19 participants. Completed in 14 April 2021.

Timeline

2 October 2019

Primary endpoint
18 December 2019

14 April 2021

Quick facts

Lead sponsor	University Ghent
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	basic science
Enrollment	19
Start date	2 October 2019
Primary completion	18 December 2019
Estimated completion	14 April 2021
Sites	1 location across Belgium

Drugs / interventions tested

Lactose (Lactose) — full drug profile →
Fexofenadine Hydrochloride — full drug profile →
Famotidine (famotidine) — full drug profile →
High-intensity interval training (HIIT)

Conditions studied

Exercise Training — all drugs for Exercise Training →
Physical Activity — all drugs for Physical Activity →

Sponsor

University Ghent

Who can join

Adults 18 to 50, male only, with Exercise Training or Physical Activity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans.
Van der Stede T, Blancquaert L, Stassen F, Everaert I, et al · · 2021 · cited 28× · PMID 33853781 · DOI 10.1126/sciadv.abf2856
Repurposing of H1-receptor antagonists (levo)cetirizine, (des)loratadine, and fexofenadine as a case study for systematic analysis of trials on clinicaltrials.gov using semi-automated processes with custom-coded software.
Specht T, Seifert R. · · 2024 · cited 5× · PMID 37870580 · DOI 10.1007/s00210-023-02796-9

Verify or expand the search:

Other trials of Lactose

Trials testing the same drug.

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NCT04924530 — Effect of Lactose on Blood Lipids · NA · completed
NCT03497598 — Preventing Recurrent Urinary Tract Infections With α-D-mannose · Phase 4 · terminated
NCT03476447 — Rescuing the Microbiome Effectively With Different Doses of B. Infantis in Infants · NA · completed
NCT03121222 — The Effects of N-acetylcysteine on Performance and Redox Homeostasis · Phase 2 · completed

Other recruiting trials for Exercise Training

Currently open trials in the same condition.

NCT07322939 — Effects of Exercise With Visual Feedback in Parkinson's Disease · NA · recruiting
NCT07164911 — Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction · recruiting
NCT07216755 — Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude · NA · recruiting
NCT07128030 — Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study · NA · recruiting
NCT06453473 — Transfer Effects of Stationary Bicycle Perturbation Training on Older Adults' Cycling Skills · NA · recruiting

Other University Ghent trials

Trials by the same sponsor.

NCT07398053 — General Practitioner & Pharmacist Support for Discontinuing Long-term Antidepressants in Clinically Stable Patients · NA · not yet recruiting
NCT07343258 — Pilot Study on Follow-Up of (Acutely) Suicidal Individuals From the Flemish Suicide Helpline · NA · recruiting
NCT07091071 — Evaluation of the CochSyn Device in Clinical Practice · NA · completed
NCT07259408 — Co-creation of Tools for People in Detention With Suicidal Thoughts and/or Behavior · recruiting
NCT07176156 — Evaluation of the Quality of Chat Conversations With the Suicide Helpline Zelfmoordlijn 1813 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04450134 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Ghent
Last refreshed: 7 June 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04450134.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing