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NCT04447144

Nutritional Habits, and Coronavirus Disease 2019 (COVID-19) Outcome

Status unknown Last updated 30 June 2020
What this trial tests

trial in Covid19 in 200 participants. Status unknown.

Timeline
1 June 2020
Primary endpoint
1 August 2020
1 September 2020

Quick facts

Lead sponsorCairo University
StatusStatus unknown
Study typeOBSERVATIONAL
Enrollment200
Start date1 June 2020
Primary completion1 August 2020
Estimated completion1 September 2020
Sites1 location across Egypt

Conditions studied

Sponsor

Cairo University

Who can join

Adults 18 to 80, any sex, with Covid19 or Chronic Inflammation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

As of May 30th more than 23,000 cases of COVID -19 cases were confirmed in Egypt with total deaths of 913. Post viral entry, intense immune response against the virus with infiltration of monocytes and macrophages into alveolar cells with decreasing number of lymphocytes in peripheral blood along with reduced lymphocytes in lymphoid organs, hypercoagulability, thrombosis and multiple organ damage, The gut microbiota and immune homeostasis seem to have a back and forth relationship. Also, gut microbiota derived signals are known to tune the immune cells for pro and anti-inflammatory responses thereby affecting the susceptibility to various diseases. Healthy gut microbiome essentially could be pivotal in maintaining an optimal immune system to prevent an array of excessive immune reactions that eventually become detrimental to lungs and vital organ systems. Numerous studies have shown that the patient's nutritional status have a significant effect on an individual's immunity and over all health status and it has been suggested that nutritional deficiencies may predispose to severe forms of COVID-19 infections. Co-existing non-communicable chronic diseases (NCDs) in COVID-19 patients have been found to delay patients recovery and worsen their prognosis, the reason may be due to aggravated inflammatory pathology found in NCDs exacerbating COVID-19 infection. The aim of the study is to evaluate the role dietary habits among COVID-19 Egyptian patients and whether type of diet (Mediterranean or Western) will affect disease outcomes

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Gut Microbiota Dysbiosis-Immune Hyperresponse-Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches.
    Ferreira C, Viana SD, Reis F. · · 2020 · cited 44× · PMID 33019592 · DOI 10.3390/microorganisms8101514
  2. Beyond probiotic legend: ESSAP gut microbiota health score to delineate SARS-COV-2 infection severity.
    Hegazy M, Hegazy M, Ahmed Ashoush O, Tharwat Hegazy M, et al · · 2022 · cited 26× · PMID 34096487 · DOI 10.1017/s0007114521001926
  3. Targeting the Gut Microbiota in Coronavirus Disease 2019: Hype or Hope?
    Lau HC, Ng SC, Yu J. · · 2022 · cited 16× · PMID 34508775 · DOI 10.1053/j.gastro.2021.09.009
  4. The Role of an Anti-Inflammatory Diet in Conjunction to COVID-19.
    Ling V, Zabetakis I. · · 2021 · cited 12× · PMID 34842636 · DOI 10.3390/diseases9040076
  5. Exploring the Interplay between COVID-19 and Gut Health: The Potential Role of Prebiotics and Probiotics in Immune Support.
    Giovanetti M, Pannella G, Altomare A, Rocchi G, et al · · 2024 · cited 6× · PMID 38543736 · DOI 10.3390/v16030370
  6. Beneficial role of healthy eating Index-2015 score & physical activity on COVID-19 outcomes.
    Hegazy MA, Fouad MM, Abd Elshafy SA, Abdelfatah D, et al · · 2023 · cited 4× · PMID 37784193 · DOI 10.1186/s40795-023-00727-8
  7. From Microbial Ecology to Clinical Challenges: The Respiratory Microbiome's Role in Antibiotic Resistance.
    Niculescu AG, Mitache MM, Grumezescu AM, Chifiriuc MC, et al · · 2025 · cited 3× · PMID 40333133 · DOI 10.3390/pathogens14040355

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Data sources for this page

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