NCT04445350: MLKOA

Motor Learning in Knee Osteoarthritis

Status unknown NA Last updated 24 June 2020

What this trial tests

NA trial testing External Focus Of Attention in Knee Osteoarthritis in 50 participants. Status unknown.

Timeline

1 November 2018

Primary endpoint
28 February 2022

30 April 2022

Quick facts

Lead sponsor	St. Pölten University of Applied Sciences
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	50
Start date	1 November 2018
Primary completion	28 February 2022
Estimated completion	30 April 2022
Sites	1 location across Austria

Drugs / interventions tested

• External Focus Of Attention
• Internal Focus Of Attention

Conditions studied

• Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
• Lower Extremity Biomechanics — all drugs for Lower Extremity Biomechanics →
• Physiotherapy — all drugs for Physiotherapy →

Sponsor

St. Pölten University of Applied Sciences

Who can join

Adults 45 to 60, any sex, with Knee Osteoarthritis or Lower Extremity Biomechanics. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Non-surgical treatment options, like exercise therapy, show excellent short-term effects regarding pain reduction and improvement of knee function. However, mid- and long-term effects are missing so far. This might indicate that long-lasting changes in motor-skill performance (Motor Learning) have not occurred. Motor learning is associated with permanent changes in the capability for skilled movement behavior avoiding unfavorable joint loads and inappropriate muscle activation patterns, leading to compensatory movement strategies. One-sided and high repetitive loads in the knee joint could be one reason for the progression of knee osteoarthritis. Physiotherapeutic strategies should therefore be able to stimulate motor learning processes. In physiotherapy, motor learning can be optimized by using instructions and feedback, targeting an external focus of attention, when learning specific movement patterns. This study investigates the effects of a 12 week exercise therapy program, using an external focus of attention, on functional and biomechanical parameters in patients with knee osteoarthritis. To measure possible changes, functional measurements are taking place at baseline, after 6, 12 and 24 weeks. The biomechanical measurements (3D gait analysis) are taking place at baseline, after 12 and 24 weeks.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Exercise for osteoarthritis of the knee.
   Lawford BJ, Hall M, Hinman RS, Van der Esch M, et al · · 2024 · cited 37× · PMID 39625083 · DOI 10.1002/14651858.cd004376.pub4
2. Artificial-Intelligence-Aided Radiographic Diagnostic of Knee Osteoarthritis Leads to a Higher Association of Clinical Findings with Diagnostic Ratings.
   Neubauer M, Moser L, Neugebauer J, Raudner M, et al · · 2023 · cited 17× · PMID 36769394 · DOI 10.3390/jcm12030744