Who is sponsoring NCT04439669?

NCT04439669 is sponsored by Helsinki University Central Hospital.

What drugs are being tested in NCT04439669?

Interventions in NCT04439669: Sham nrTMS and open phase, Active nrTMS and open phase.

What condition does NCT04439669 study?

NCT04439669 studies Transcranial Magnetic Stimulation, Complex Regional Pain Syndrome of Upper Limb (Disorder).

Is NCT04439669 still recruiting?

NCT04439669 is currently completed. Last updated 3 July 2024.

Last reviewed 2024-07-03 · How we verify

NCT04439669

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

CRPS - Diagnostics, Pathophysiological Mechanisms, and Response to Treatment With Noninvasive Brain Stimulation

Completed NA Last updated 3 July 2024

What this trial tests

NA trial testing Sham nrTMS and open phase in Transcranial Magnetic Stimulation in 62 participants. Completed in 25 August 2022.

Timeline

28 August 2017

Primary endpoint
29 July 2021

25 August 2022

Quick facts

Lead sponsor	Helsinki University Central Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	62
Start date	28 August 2017
Primary completion	29 July 2021
Estimated completion	25 August 2022
Sites	2 locations across Finland

Drugs / interventions tested

Sham nrTMS and open phase
Active nrTMS and open phase

Conditions studied

Transcranial Magnetic Stimulation — all drugs for Transcranial Magnetic Stimulation →
Complex Regional Pain Syndrome of Upper Limb (Disorder) — all drugs for Complex Regional Pain Syndrome of Upper Limb (Disorder) →

Sponsor

Helsinki University Central Hospital

Who can join

18 and older, any sex, with Transcranial Magnetic Stimulation or Complex Regional Pain Syndrome of Upper Limb (Disorder). Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a sham controlled, randomized, double-blind, navigated repetitive Transcranial Magnetic Stimulation (nrTMS) study for the treatment of complex regional pain syndrome (CRPS types 1 and 2). The investigators study factors that may contribute to development, maintenance, or treatment responses with clinical, sleep, and psychiatric questionnaires and clinical examinations, quantitative sensory testing and neurophysiologic recordings, genetics, and MRI techniques.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

rTMS targeted to the secondary somatosensory cortex influences sleep in CRPS patients, as measured with the OURA ring.
Vanhanen J, Kujala J, Liljeström M, Kalso E, et al · · 2023 · cited 5× · PMID 37700567 · DOI 10.1002/brb3.3252
Cognitive Function in Patients With Complex Regional Pain Syndrome (CRPS).
Liesto S, Aho T, Jääskeläinen SK, Hietanen M, et al · · 2025 · cited 1× · PMID 40626344 · DOI 10.1002/ejp.70070

Verify or expand the search:

Other recruiting trials for Transcranial Magnetic Stimulation

Currently open trials in the same condition.

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Other Helsinki University Central Hospital trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04439669 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Helsinki University Central Hospital
Last refreshed: 3 July 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04439669.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing