NCT04437992 (SAPERER) is a clinical trial of NIPT in Autosomal Aneuploidy, sponsored by Azienda Usl di Bologna.

Who is sponsoring NCT04437992?

NCT04437992 is sponsored by Azienda Usl di Bologna.

What drugs are being tested in NCT04437992?

Interventions in NCT04437992: NIPT.

What condition does NCT04437992 study?

NCT04437992 studies Autosomal Aneuploidy.

Is NCT04437992 still recruiting?

NCT04437992 is currently status unknown. Last updated 24 July 2020.

Last reviewed 2020-07-24 · How we verify

NCT04437992: SAPERER

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Feasibility Study of a New Screening Program for Major Aneuploidies (T21, T18, T13) in the Emilia-Romagna Region (SAPERER)

Status unknown Last updated 24 July 2020

What this trial tests

trial testing NIPT in Autosomal Aneuploidy in 7,000 participants. Status unknown.

Timeline

27 January 2020

Primary endpoint
27 April 2021

27 April 2021

Quick facts

Lead sponsor	Azienda Usl di Bologna
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	7,000
Start date	27 January 2020
Primary completion	27 April 2021
Estimated completion	27 April 2021
Sites	1 location across Italy

Drugs / interventions tested

NIPT

Conditions studied

Autosomal Aneuploidy — all drugs for Autosomal Aneuploidy →

Sponsor

Azienda Usl di Bologna — full company profile →

Who can join

18 and older, female only, with Autosomal Aneuploidy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The study is promoted by the Emilia Romagna Region which identified in the Bologna AUSL the coordinating center (Unità Operativa Complessa Laboratorio Unico Metropolitano, LUM, Maggiore Hospital). The medical genetics centers, participating in the technical-scientific coordination group of assessment (resolution No. 1894, 4/11/2019), the family counseling centers and the region prenatal hospital clinics are involved as collaborative experimental centers. Currently, 14,400 combined tests are carried out in the Emilia Romagna Region every year. As a result offering the new non-invasive NIPT test, it is estimated that the number of participants in the screening program will increase by up to 20,000/year. The study will collect data on the women who will access the combined test in the first 9 months of the protocol and join the enrollment.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Screening for major aneuploidies at 10 weeks of gestation in an unselected population: comparing the combined test to the non-invasive prenatal testing with rolling-circle replication (SAPERER study).
Cerreta V, Musti MA, Simonazzi G, Frazzoni A, et al · · 2026 · PMID 41775005 · DOI 10.1016/j.ejogrb.2026.115035

Verify or expand the search:

Other trials of NIPT

Trials testing the same drug.

NCT06089746 — Lumbosacral Spinal Stenosis - Non-Invasive Postural Therapy for Older Adult Veterans · NA · recruiting
NCT05618431 — Validate Non-invasive Prenatal Tests for the Detection of Chromosomal Abnormalities · NA · unknown
NCT05798858 — A Pilot Study for Implementation of First Trimester Screening of Aneuploidies in Campania Region · NA · unknown
NCT04595201 — Clinical Follow-up of Pregnant Subjects Undergoing NIPT · recruiting
NCT04049604 — IDENTIFY Study: Natural History of Maternal Neoplasia · NA · recruiting

Other Azienda Usl di Bologna trials

Trials by the same sponsor.

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NCT06471231 — Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock · Phase 4 · recruiting
NCT06750822 — Accuracy of Automatic Contusion Volume Scanning for Predicting the Incidence of Pneumonia in Patients With Thoracic Trau · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04437992 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Azienda Usl di Bologna
Last refreshed: 24 July 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04437992.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing