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Antibiotic Dosing in Geriatric Patients At the Emergency Department (AGED)
In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate, Piperacillin-Tazobactam and Temocillin) are attained in frail patients admitted to the geriatric department.
Details
| Lead sponsor | University Hospital, Ghent |
|---|---|
| Status | RECRUITING |
| Enrolment | 180 |
| Start date | 2018-01-03 |
| Completion | 2025-01 |
Conditions
- Elderly Infection
- Frailty
- Frail Elderly Syndrome
- Infection, Bacterial
Interventions
- Blood sampling
- Sputum sample
- Hemoculture
- Urine sample
Primary outcomes
- Blood concentrations of amoxicillin-clavulanate. — Within the first 12 hours (early dose) of treatment and after 24 - 48 hours of treatment (steady state)
To investigate whether blood concentrations with maximum antimicrobial activity are achieved with current dosing regimens in first-dose or early-dose conditions and in steady-state conditions. - Blood concentrations of piperacillin-tazobactam. — Within the first 12 hours (early dose) of treatment and after 24 - 48 hours of treatment (steady state)
To investigate whether blood concentrations with maximum antimicrobial activity are achieved with current dosing regimens in first-dose or early-dose conditions and in steady-state conditions. - Blood concentrations of temocillin. — Within the first 12 hours (early dose) of treatment and after 24 - 48 hours of treatment (steady state)
To investigate whether blood concentrations with maximum antimicrobial activity are achieved with current dosing regimens in first-dose or early-dose conditions and in steady-state conditions.
Countries
Belgium