NCT04434794 is a Phase 1, PHASE2 clinical trial of mesenchymal stem cells in Gingival Recession, sponsored by Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus.

What drugs are being tested in NCT04434794?

Interventions in NCT04434794: mesenchymal stem cells, standard treatment.

What condition does NCT04434794 study?

NCT04434794 studies Gingival Recession.

Is NCT04434794 still recruiting?

NCT04434794 is currently completed. Last updated 17 June 2020.

Last reviewed 2020-06-17 · How we verify

NCT04434794

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Gingival Recession Using Mesenchymal Stem Cells

Completed Phase 1, PHASE2 Last updated 17 June 2020

What this trial tests

Phase 1, PHASE2 trial testing mesenchymal stem cells in Gingival Recession in 27 participants. Completed in 31 December 2019.

Timeline

1 January 2018

Primary endpoint
31 December 2019

31 December 2019

Quick facts

Lead sponsor	Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Phase	Phase 1, PHASE2
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	27
Start date	1 January 2018
Primary completion	31 December 2019
Estimated completion	31 December 2019
Sites	1 location across Belarus

Drugs / interventions tested

mesenchymal stem cells — full drug profile →
standard treatment

Conditions studied

Gingival Recession — all drugs for Gingival Recession →

Sponsor

Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

Who can join

Adults 18 to 80, any sex, with Gingival Recession. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Treatment of patients with gingival recession by injection of autologous adipose-derived mesenchymal stem cells mixed with collagen gel

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

The Clinical Trials of Mesenchymal Stromal Cells Therapy.
Kouchakian MR, Baghban N, Moniri SF, Baghban M, et al · · 2021 · cited 30× · PMID 34745268 · DOI 10.1155/2021/1634782
Mesenchymal Stromal Cells Derived from Dental Tissues: Immunomodulatory Properties and Clinical Potential.
Poblano-Pérez LI, Castro-Manrreza ME, González-Alva P, Fajardo-Orduña GR, et al · · 2024 · cited 13× · PMID 38396665 · DOI 10.3390/ijms25041986
Current Perspectives on Mesenchymal Stem Cells as a Potential Treatment for Periodontal Diseases and Conditions.
Cai S, Li C, Wei B, Ye Z, et al · · 2025 · cited 2× · PMID 40838652 · DOI 10.1002/dvg.70024

Verify or expand the search:

Other trials of mesenchymal stem cells

Trials testing the same drug.

NCT06416709 — Stem Cell Treatment for Lung Injury Caused by Major Infectious Diseases · Phase 1, PHASE2 · recruiting
NCT04446897 — Treatment of Chronic Medium-severe Periodontitis With Mesenchymal Stem Cells Predifferentiated in Osteogenic Direction · Phase 1, PHASE2 · completed
NCT04371601 — Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019 · EARLY_PHASE1 · unknown
NCT03562065 — Treatment of Refractory Systemic Lupus Erythematosus by Allogeneic Mesenchymal Stem Cells Derived From the Umbilical Cor · Phase 1, PHASE2 · unknown
NCT03550183 — Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Parkinson's Disease · Phase 1 · unknown

Other recruiting trials for Gingival Recession

Currently open trials in the same condition.

NCT07513792 — The Impact of a 3D Imaging Tool on Reducing Gum Recession During Orthodontic Treatment With Aligners · NA · recruiting
NCT07437417 — A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth · NA · recruiting
NCT07158541 — Comparing TCAF and MTUN With Soft Tissue Grafting for Treating Single Recessions in the Premandible · NA · recruiting
NCT07104019 — Biofiller and Gingival Phenotype Thickening · NA · recruiting
NCT07291583 — Hyaluronic Acid With Connective Tissue Grafting for Gingival Recession · NA · active not recruiting

Other Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus trials

Trials by the same sponsor.

NCT06167564 — Allergy Diagnostic Test Based on Microchip Technology · NA · unknown
NCT05654766 — Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies · unknown
NCT05520125 — Treatment of Patients With Bone Tissue Defects Using Mesenchymal Stem Cells Enriched by Extracellular Vesicles · Phase 1, PHASE2 · unknown
NCT05520112 — Treatment of Recurrent Pregnancy Loss Using Mesenchymal Stem Cells · Phase 1, PHASE2 · unknown
NCT05214014 — Treatment of Systemic Sclerosis With Autologous Regulatory Т-cells · Phase 1, PHASE2 · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04434794 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
Last refreshed: 17 June 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04434794.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing