NCT04432935 is a NA clinical trial of Bovine Lactoferrin in Poliomyelitis, sponsored by Aga Khan University.

Who is sponsoring NCT04432935?

NCT04432935 is sponsored by Aga Khan University.

What drugs are being tested in NCT04432935?

Interventions in NCT04432935: Bovine Lactoferrin, Placebo Glucon D.

What condition does NCT04432935 study?

NCT04432935 studies Poliomyelitis.

Is NCT04432935 still recruiting?

NCT04432935 is currently completed. Last updated 16 August 2023.

Last reviewed 2023-08-16 · How we verify

NCT04432935

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Lactoferrin on Polio Seroconversion

Completed NA Last updated 16 August 2023

What this trial tests

NA trial testing Bovine Lactoferrin in Poliomyelitis in 468 participants. Completed in 30 June 2022.

Timeline

1 October 2020

Primary endpoint
30 June 2022

30 June 2022

Quick facts

Lead sponsor	Aga Khan University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	468
Start date	1 October 2020
Primary completion	30 June 2022
Estimated completion	30 June 2022
Sites	1 location across Pakistan

Drugs / interventions tested

Bovine Lactoferrin — full drug profile →
Placebo Glucon D

Conditions studied

Poliomyelitis — all drugs for Poliomyelitis →

Sponsor

Aga Khan University

Who can join

Adults 1 Hour to 23 Hours, any sex, with Poliomyelitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A massive decline in cases of poliomyelitis was observed worldwide since 1988; however its transmission continues in Pakistan and Afghanistan. In 2017, a total of 17 cases were reported from these countries, which represent approximately half of the cases reported in 2016. This achievement was made possible by large scale use of oral polio vaccine (OPV) and inactivated polio vaccine (IPV). Despite vigorous efforts to end poliovirus transmission in endemic areas, several challenges including illiteracy, poverty, malnutrition, difficulty to access health and immunization services adversely affect the effectiveness of the polio eradication efforts. Innovations are thus needed to accomplish the goal of eradication as due to limited funding, the sustainability of a program becomes questionable. The aim of this study is to assess the effectiveness of lactoferrin in increasing mucosal and serum immunity in children following administration of poliovirus vaccines.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review.
Sinopoli A, Isonne C, Santoro MM, Baccolini V. · · 2022 · cited 26× · PMID 34133812 · DOI 10.1002/rmv.2261
Effect of bovine lactoferrin on seroconversion following polio vaccine administration in children: protocol for a double-blinded randomised controlled trial.
Habib A, Nausheen S, Nooruddin S, Javed T, et al · · 2022 · PMID 35613782 · DOI 10.1136/bmjopen-2021-050849

Verify or expand the search:

Other trials of Bovine Lactoferrin

Trials testing the same drug.

NCT04526821 — Lactoferrin for Prevention of COVID-19 in Health Care Workers · Phase 2 · terminated
NCT03367013 — Lactoferrin Infant Feeding Trial - LIFT_Canada · Phase 3 · completed
NCT06109688 — Effect of Lactoferrin Supplementation on Urinary Tract Infections in Infants. · Phase 3 · completed

Other recruiting trials for Poliomyelitis

Currently open trials in the same condition.

NCT07457060 — Phase IV Clinical Study of Sequential Vaccination of Sabin Strain and Wild Strain Inactivated Poliovirus Vaccine · Phase 4 · recruiting
NCT06895486 — Study of Co-administered (Types 1 & 2) Novel Oral Poliomyelitis Vaccines Evaluation · Phase 2 · recruiting
NCT07354269 — Phase IV Clinical Study of sIPV Administration in Adolescent and Adult Populations · Phase 4 · recruiting
NCT06137664 — Study of Trivalent and Bivalent (Types 1 & 2) Novel Oral Poliomyelitis Vaccines · Phase 1, PHASE2 · recruiting
NCT05644184 — Study of a Novel Type 1 Oral Poliomyelitis Vaccine in Bangladesh · Phase 2 · recruiting

Other Aga Khan University trials

Trials by the same sponsor.

NCT07475793 — Image Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis · NA · not yet recruiting
NCT07197684 — Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surg · NA · not yet recruiting
NCT07356063 — Self-Efficacy Enhancement Using a Multicomponent Support Group for Caregivers of Children With DMD/SMA · NA · not yet recruiting
NCT07451951 — Effectiveness of SQLNS vs MQLNS for Prevention of Undernutrition in Children 6-12 Months · NA · not yet recruiting
NCT07357350 — Effectiveness of Pain Management Interventions in Patients With Abdominal and Pelvic Cancer · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04432935 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Aga Khan University
Last refreshed: 16 August 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04432935.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing