Echocardiographic Study of a Single Dose Bisoprolol Versus Nebivolol in Healthy Subjects: a Randomized, Double-blind, Cross-over Study (BINEB)

NCT04432610 Phase 4 WITHDRAWN

This is a randomized, double-blind, crossover study in healthy adult subjects. Each subject will receive a single dose of bisoprolol 5 mg p.o. and nebivolol 5 mg p.o. with 1 week washout period. All subjects will undergo a physical examination, 12-lead electrocardiography and a comprehensive echocardiographic study before the administration of the study drug and 5 hours thereafter.

Details

Lead sponsor	Clinical Hospital Center Zemun
Phase	Phase 4
Status	WITHDRAWN
Start date	2030-01
Completion	2030-12

Conditions

• Bisoprolol Adverse Reaction
• Nebivolol Adverse Reaction

Interventions

• Bisoprolol versus Nebivolol

Primary outcomes

• Relative change (%) of cardiac output (CO) — Pre- and 5 hours post study drug administration
  CO (l/min), will be assessed by calculating stroke volume using pulsed-wave doppler (velocity time integral)

Countries

Serbia