Efficacy of a Zinc-L-Carnosine -Based Mouth Rinse on Periodontal Tissues and Pain After Scaling and Root Planing - a Randomized Clinical Trial; a Randomized Controlled Trial

NCT04430998 Phase 3 UNKNOWN

A clinical trial to assess the effect of a Zinc-L-Carnosine-based mouth rinse on periodontal tissues and pain after scaling and root planing

Details

Lead sponsor	University of Milan
Phase	Phase 3
Status	UNKNOWN
Enrolment	75
Start date	2020-06
Completion	2020-06-30

Conditions

• Periodontal Index
• Pain

Interventions

• Zinc L-Carnosine
• Chlorhexidine
• Water

Primary outcomes

• Change in Healing Index (H.I.) — 0, 7, 21 days
  The Laundry-Turnbull and Howley index will be used to evaluate healing, considering the changes made by Pippi et al. In 2015. In particular, seven parameters will be assessed, to each of which a value of 1 or 0 will be assigned. The sum of the values will indicate the degree of healing to be compared between the different groups. These seven parameters are: redness of mucosa, granulation tissue, suppuration, swelling, re-epithelialization, bleeding, pain on palpation. Higher score means worse outcome.
• Change in the Visual Analogue Scale (VAS) of pain — 0, 7, 21 days
  Participants will be asked to mark the perceived degree of pain on a scale of 100 dashes, with the lowest score being "no pain" and the highest "the worst pain". Higher score means worse outcome.

Countries

Italy