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NCT04428398: PRE-FLARED
Urinary T Lymphocytes Predict Renal Flares in Patients With Inactive ANCA-associated Glomerulonephritis
trial testing Analysis of urine samples with flow cytometry in Glomerulonephritis Acute in 100 participants. Completed in 1 September 2021.
1 September 2021
Quick facts
| Lead sponsor | Charite University, Berlin, Germany |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 100 |
| Start date | 1 May 2020 |
| Primary completion | 1 September 2021 |
| Estimated completion | 1 September 2021 |
| Sites | 2 locations across Germany |
Drugs / interventions tested
- Analysis of urine samples with flow cytometry
Conditions studied
- Glomerulonephritis Acute — all drugs for Glomerulonephritis Acute →
Sponsor
Charite University, Berlin, Germany
Who can join
18 and older, any sex, with Glomerulonephritis Acute. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Urinary CD4+ and CD8+ T lymphocytes may predict renal flares in patients with inactive ANCA-associated vasculitis and thus serve as early non-invasive biomarkers. Urine samples of patients with inactive renal ANCA-vasculitis will be analysed by flow cytometry and compared to clinical outcome after 6 months.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
HES and EGPA: Two Sides of the Same Coin.
Khoury P, Akuthota P, Kwon N, Steinfeld J, et al · · 2023 · cited 21× · PMID 37419574 · DOI 10.1016/j.mayocp.2023.02.013 -
Urinary CD4 + T Cells Predict Renal Relapse in ANCA-Associated Vasculitis.
Prskalo L, Skopnik CM, Goerlich N, Freund P, et al · · 2024 · cited 16× · PMID 38231590 · DOI 10.1681/asn.0000000000000311 -
From clinical management to personalized medicine: novel therapeutic approaches for ovarian clear cell cancer.
Liu Z, Jing C, Kong F. · · 2024 · cited 12× · PMID 38347608 · DOI 10.1186/s13048-024-01359-7
Verify or expand the search:
- PubMed search for NCT04428398
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04428398 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Charite University, Berlin, Germany
- Last refreshed: 14 November 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04428398.
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