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NCT04426838
Cognitive Behavioral Therapy for Insomnia for the Dementia Caregiving Dyad
NA trial testing Cognitive Behavioral Therapy for Insomnia (CBTi) via Videoconference in Cognitive Impairment in 44 participants. Completed in 10 March 2023.
10 March 2023
Quick facts
| Lead sponsor | Emory University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Enrollment | 44 |
| Start date | 30 September 2020 |
| Primary completion | 10 March 2023 |
| Estimated completion | 10 March 2023 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Cognitive Behavioral Therapy for Insomnia (CBTi) via Videoconference
Conditions studied
- Cognitive Impairment — all drugs for Cognitive Impairment →
- Dementia — all drugs for Dementia →
Sponsor
Emory University
Who can join
18 and older, any sex, with Cognitive Impairment or Dementia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Disturbed sleep is stressful to persons living with dementia (PLwD) and their caregivers. It contributes to earlier placement of the PLwD in nursing homes and increase the risk for many psychological and cognitive health issues and poor quality of life for both the PLwD and the caregivers. Given the potential harmful side effects of medications, non-medication alternatives, such as Cognitive Behavioral Therapy for Insomnia (CBTi), may be safer to improve disturbed sleep in this population. CBTi which includes stimulus control, sleep compression, relaxation, sleep hygiene, and cognitive restructuring, is effective and has durable and sustained effects on sleep outcomes over the long-term. CBTi has improved sleep disturbances in PLwD and their caregivers, separately. Since disturbed sleep in the PLwD-caregiver dyad is bidirectional and interdependent, targeting the pair as a unit for intervention has the potential to lead to improved sleep and health outcomes for both persons. There is no current published research on CBTi when the PLwD and their caregivers receive the intervention at the same time; as a result, the researchers will examine the 1) feasibility; 2) acceptability; and 3) preliminary efficacy of 4-week CBTi intervention for community-dwelling PLwD and their caregivers who are both experiencing sleep disturbances. Forty PLwD-caregiver dyads will receive CBTi via videoconferencing sessions. Preliminary efficacy of the intervention will be assessed using objective (actigraphy) and subjective sleep quality measures. In addition, semi-structured interviews will be conducted to examine the acceptability and satisfaction with the intervention.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Psychological treatments for depression and anxiety in dementia and mild cognitive impairment.
Orgeta V, Leung P, Del-Pino-Casado R, Qazi A, et al · · 2022 · cited 47× · PMID 35466396 · DOI 10.1002/14651858.cd009125.pub3
Verify or expand the search:
- PubMed search for NCT04426838
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04426838 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Emory University
- Last refreshed: 20 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04426838.
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