NCT04425967: SCOPES

Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas

Active, enrolled NA Last updated 20 January 2026

What this trial tests

NA trial testing pre-operative radiotherapy in Soft Tissue Sarcomas in 168 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

25 June 2021

Primary endpoint
1 May 2026

1 May 2031

Quick facts

Lead sponsor	The Netherlands Cancer Institute
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	168
Start date	25 June 2021
Primary completion	1 May 2026
Estimated completion	1 May 2031
Sites	4 locations across Netherlands

Drugs / interventions tested

• pre-operative radiotherapy

Conditions studied

• Soft Tissue Sarcomas — all drugs for Soft Tissue Sarcomas →

Sponsor

The Netherlands Cancer Institute

Who can join

18 and older, any sex, with Soft Tissue Sarcomas. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Currently, soft tissue sarcomas (STS) are preoperatively irradiated in a conventionally fractionated regimen of 25 x 2 Gy in five weeks. Recent radiobiological investigations, however, suggest sensitivity to (modest) hypofractionation. Within this study, patients will be randomized to receive either the conventional schedule of 25 x 2 Gy or a shorter preoperative regimen of 14 x 3 Gy, in the hypothesis that both the postoperative wound complication rate until 30 days after surgery, as well as the local control probability at two years are comparable in both arms.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

1. Hypofractionated, 3-week, preoperative radiotherapy for patients with soft tissue sarcomas (HYPORT-STS): a single-centre, open-label, single-arm, phase 2 trial.
   Guadagnolo BA, Bassett RL, Mitra D, Farooqi A, et al · · 2022 · cited 54× · PMID 36343656 · DOI 10.1016/s1470-2045(22)00638-6
2. Preoperative hypofractionated radiotherapy for soft tissue sarcomas: a systematic review.
   Roohani S, Ehret F, Kobus M, Flörcken A, et al · · 2022 · cited 25× · PMID 36104789 · DOI 10.1186/s13014-022-02072-9
3. Radiation Therapy in Adult Soft Tissue Sarcoma-Current Knowledge and Future Directions: A Review and Expert Opinion.
   Roeder F. · · 2020 · cited 22× · PMID 33153100 · DOI 10.3390/cancers12113242
4. Evaluating Thresholds to Adopt Hypofractionated Preoperative Radiotherapy as Standard of Care in Sarcoma.
   Valle LF, Bernthal N, Eilber FC, Shabason JE, et al · · 2021 · cited 9× · PMID 34720663 · DOI 10.1155/2021/3735874
5. Update on Dosing and Fractionation for Neoadjuvant Radiotherapy for Localized Soft Tissue Sarcoma.
   Roohani S, Wiltink LM, Kaul D, Spałek MJ, et al · · 2024 · cited 8× · PMID 38478330 · DOI 10.1007/s11864-024-01188-2
6. Diagnosis and treatment of primary soft tissue sarcomas: comprehensive review.
   Dossa F, Elnekave E, Miah AB, Mitchell C, et al · · 2025 · PMID 41802245 · DOI 10.1093/bjsopen/zraf177
7. Preoperative hypofractionated radiotherapy in soft tissue sarcomas: institutional experience and clinical implications.
   Guzmán-Gómez L, Morón C, Martín-Broto J, Hindi N, et al · · 2026 · PMID 41660490 · DOI 10.1016/j.ctro.2026.101112