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NCT04421066
Histological, Genetic and Epigenetic Analysis of Procedures Related with Dental Implants
trial testing Gingival and bone sample collection in Peri-Implantitis in 200 participants. Completed in 20 June 2022.
21 October 2021
Quick facts
| Lead sponsor | Simón Pardiñas López |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 200 |
| Start date | 29 January 2019 |
| Primary completion | 21 October 2021 |
| Estimated completion | 20 June 2022 |
| Sites | 1 location across Spain |
Drugs / interventions tested
- Gingival and bone sample collection
- Healthy individuals
Conditions studied
- Peri-Implantitis — all drugs for Peri-Implantitis →
- Peri-implant Mucositis — all drugs for Peri-implant Mucositis →
- Implant Complication — all drugs for Implant Complication →
- Implant Tissue Failure — all drugs for Implant Tissue Failure →
Sponsor
Simón Pardiñas López
Who can join
Adults 20 to 90, any sex, with Peri-Implantitis or Peri-implant Mucositis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study genomic, proteomic and histological technologies for the search and characterization of epigenetic modifications and molecular or protein markers, useful in the diagnosis and progression of peri-implant diseases and prevention of implant failure will be used.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Global DNA Methylation in Dental Implant Failure Due to Peri-Implantitis: An Exploratory Clinical Pilot Study.
Khouly I, Pardiñas López S, Díaz Prado SM, Ferrantino L, et al · · 2022 · cited 6× · PMID 35055840 · DOI 10.3390/ijerph19021020
Verify or expand the search:
- PubMed search for NCT04421066
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Peri-Implantitis
Currently open trials in the same condition.
- NCT07012915 — Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-Implantitis · NA · recruiting
- NCT06679283 — Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF) · NA · recruiting
- NCT06017817 — Antibacterial Photodynamic Therapy in the Management of Peri-implantitis · NA · recruiting
- NCT06364982 — Distance Between Dental Implants as a Risk Indicator for Peri-implant Disease. · recruiting
- NCT06288919 — Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04421066 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Simón Pardiñas López
- Last refreshed: 26 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04421066.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing