Last reviewed · How we verify
NCT04420962: AQUA
Automated Quantitative Ulcer Analysis Study
trial testing Visual Acuity in Keratitis in 124 participants. Completed in 7 June 2024.
7 June 2024
Quick facts
| Lead sponsor | University of Michigan |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 124 |
| Start date | 23 July 2020 |
| Primary completion | 7 June 2024 |
| Estimated completion | 7 June 2024 |
| Sites | 2 locations across United States, India |
Drugs / interventions tested
- Visual Acuity
Conditions studied
- Keratitis — all drugs for Keratitis →
Sponsor
University of Michigan
Who can join
Adults 15 to 99, any sex, with Keratitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a multiple site observational study that will review patient features (clinical and morphologic) over a 90 day period during care of participants with microbial keratitis with presence of clinically significant ≥2mm stromal infiltrate compared with participants with other forms of keratitis.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Open-Source Automatic Biomarker Measurement on Slit-Lamp Photography to Estimate Visual Acuity in Microbial Keratitis.
Loo J, Woodward MA, Prajna V, Kriegel MF, et al · · 2021 · cited 5× · PMID 34605877 · DOI 10.1167/tvst.10.12.2 -
The effect of social determinants of health on severity of microbial keratitis presentation at a tertiary eye care hospital in Southern India.
Annadanam A, Hicks PM, Lu MC, Pawar M, et al · · 2023 · cited 2× · PMID 37322658 · DOI 10.4103/ijo.ijo_331_23 -
Association of Deep Learning Imaging Algorithm Measures of Microbial Keratitis With Vision Outcomes.
Vogt EL, Niziol LM, Yang Z, Wang Y, et al · · 2025 · cited 1× · PMID 41247284 · DOI 10.1097/ico.0000000000004029 -
Deep Learning-Based Classification of Slit-Lamp Photograph Quality in Microbial Keratitis.
Ong J, Lu MC, Thanitcul C, Pawar M, et al · · 2026 · PMID 41816093 · DOI 10.1016/j.xops.2026.101086 -
Self-knowledge distillation-empowered directional connectivity transformer for microbial keratitis biomarkers segmentation on slit-lamp photography.
Yang Z, Woodward MA, Niziol LM, Pawar M, et al · · 2025 · PMID 40117989 · DOI 10.1016/j.media.2025.103533 -
Social Risk Factors Associated With Microbial Keratitis.
Lee MC, Vogt EL, Hicks PM, Pawar M, et al · · 2026 · PMID 39661074 · DOI 10.1097/ico.0000000000003766
Verify or expand the search:
- PubMed search for NCT04420962
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT05611073 — Maximizing Visual Outcomes With Eyhance IOLs · completed
- NCT05226884 — Intermediate Vision in Patients With Clareon IOLs Compared to Eyhance IOLs · completed
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04420962 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Michigan
- Last refreshed: 2 May 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04420962.
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