NCT04411459 is a clinical trial of Invasive mechanical ventilation in COVID-19, sponsored by Azienda Usl di Bologna.

Who is sponsoring NCT04411459?

NCT04411459 is sponsored by Azienda Usl di Bologna.

What drugs are being tested in NCT04411459?

Interventions in NCT04411459: Invasive mechanical ventilation.

What condition does NCT04411459 study?

NCT04411459 studies COVID-19, Mechanical Ventilation, Quality of Life, Radiologic Increased Density of Lung, Sedation, Complication of Treatment.

Is NCT04411459 still recruiting?

NCT04411459 is currently completed. Last updated 30 August 2021.

Last reviewed 2021-08-30 · How we verify

NCT04411459

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome

Completed Last updated 30 August 2021

What this trial tests

trial testing Invasive mechanical ventilation in COVID-19 in 470 participants. Completed in 16 October 2020.

Timeline

1 February 2020

Primary endpoint
30 June 2020

16 October 2020

Quick facts

Lead sponsor	Azienda Usl di Bologna
Status	Completed
Study type	OBSERVATIONAL
Enrollment	470
Start date	1 February 2020
Primary completion	30 June 2020
Estimated completion	16 October 2020
Sites	20 locations across Italy

Drugs / interventions tested

Invasive mechanical ventilation

Conditions studied

COVID-19 — all drugs for COVID-19 →
Mechanical Ventilation — all drugs for Mechanical Ventilation →
Quality of Life — all drugs for Quality of Life →
Radiologic Increased Density of Lung — all drugs for Radiologic Increased Density of Lung →

Sponsor

Azienda Usl di Bologna — full company profile →

Who can join

18 and older, any sex, with COVID-19 or Mechanical Ventilation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This multicentric prospective clinical practice study aims at evaluating clinical factors associated with a prolonged invasive mechanical ventilation and other outcomes such as mortality and ICU length of stay in patients affected from COVID-19 related pneumonia and ARDS.

Publications & conference data

7 peer-reviewed publications reference this trial (live from Europe PMC):

Factors influencing liberation from mechanical ventilation in coronavirus disease 2019: multicenter observational study in fifteen Italian ICUs.
Gamberini L, Tonetti T, Spadaro S, Zani G, et al · · 2020 · cited 67× · PMID 33078076 · DOI 10.1186/s40560-020-00499-4
Health-related quality of life profiles, trajectories, persistent symptoms and pulmonary function one year after ICU discharge in invasively ventilated COVID-19 patients, a prospective follow-up study.
Gamberini L, Mazzoli CA, Prediletto I, Sintonen H, et al · · 2021 · cited 66× · PMID 34717097 · DOI 10.1016/j.rmed.2021.106665
Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study.
Scaramuzzo G, Gamberini L, Tonetti T, Zani G, et al · · 2021 · cited 55× · PMID 33900484 · DOI 10.1186/s13613-021-00853-1
Quality of life of COVID-19 critically ill survivors after ICU discharge: 90 days follow-up.
Gamberini L, Mazzoli CA, Sintonen H, Colombo D, et al · · 2021 · cited 47× · PMID 33977415 · DOI 10.1007/s11136-021-02865-7
Clinical implications of microvascular CT scan signs in COVID-19 patients requiring invasive mechanical ventilation.
Dalpiaz G, Gamberini L, Carnevale A, Spadaro S, et al · · 2022 · cited 11× · PMID 35034320 · DOI 10.1007/s11547-021-01444-7
Early spontaneous breathing for acute respiratory distress syndrome in individuals with COVID-19.
Hohmann F, Wedekind L, Grundeis F, Dickel S, et al · · 2022 · cited 7× · PMID 35767435 · DOI 10.1002/14651858.cd015077
Sustained Oxygenation Improvement After First Prone Positioning Is Associated with Liberation from Mechanical Ventilation and Survival in Critically Ill COVID-19 Patients: A Cohort Study
Scaramuzzo G, Gamberini L, Tonetti T, Zani G, et al · · 2021 · DOI 10.2139/ssrn.3749215

Verify or expand the search:

Other trials of Invasive mechanical ventilation

Trials testing the same drug.

NCT05877443 — Barotrauma in Adults With Critical COVID-19 · completed
NCT03255057 — Extracorporeal CO2 Removal With the Hemolung RAS for Mechanical Ventilation Avoidance During Acute Exacerbation of COPD · NA · terminated

Other recruiting trials for COVID-19

Currently open trials in the same condition.

NCT07183709 — Safety and Immunogenicity Trial of PepGNP-COVID19 Vaccine in Adults · Phase 1 · active not recruiting
NCT07300839 — A Study to Learn About a COVID-19 Vaccine in Healthy Adults 50 Through 64 Years of Age · Phase 3 · active not recruiting
NCT07221162 — A Safety and Immunogenicity Trial of Boost-2867 Vaccine, Via Intranasal and Intramuscular Routes · Phase 1 · recruiting
NCT07215520 — Safety and Tolerability of a Newcastle Disease Virus-Based Mucosal COVID-19 Vaccine in Previously Vaccinated Adults · Phase 2 · recruiting
NCT07222384 — A Study to Learn About BNT162b2 (LP.8.1)-Adapted Vaccine Against SARS-CoV-2 in Children 5 Through 11 Years of Age That A · Phase 3 · active not recruiting

Other Azienda Usl di Bologna trials

Trials by the same sponsor.

NCT07492511 — Renal and Hepatic Abnormal Doppler Patterns in Trauma · recruiting
NCT06742645 — The Use of Brief Motivational Interviewing in Community Health Centers. · NA · recruiting
NCT06395558 — intErnet-based iNterventions FOR Cardiac arrEst suRvivors · NA · recruiting
NCT06471231 — Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock · Phase 4 · recruiting
NCT06750822 — Accuracy of Automatic Contusion Volume Scanning for Predicting the Incidence of Pneumonia in Patients With Thoracic Trau · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04411459 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Azienda Usl di Bologna
Last refreshed: 30 August 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04411459.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing