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NCT04406805: TASTE
TMAO in Patients With Severe Aortic Stenosis
trial testing Measurement of plasma and urine trimethylamine-N-oxide concentration in Aortic Stenosis in 70 participants. Status unknown.
15 February 2022
Quick facts
| Lead sponsor | Medical University of Warsaw |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 70 |
| Start date | 15 January 2019 |
| Primary completion | 15 February 2022 |
| Estimated completion | 15 February 2023 |
| Sites | 1 location across Poland |
Drugs / interventions tested
- Measurement of plasma and urine trimethylamine-N-oxide concentration
Conditions studied
- Aortic Stenosis — all drugs for Aortic Stenosis →
- Heart Failure — all drugs for Heart Failure →
Sponsor
Medical University of Warsaw
Who can join
Adults 18 to 99, any sex, with Aortic Stenosis or Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Trimethylamine N-oxide (TMAO) has recently gained increasing scientific interest in the field of cardiovascular disease, including its role in cell protection against osmotic and hydrostatic stress. Aortic stenosis (AS) is the most common valvular heart disease, affecting about 7.6 million people over 75 years of age in North America and Europe alone. We hypothesized that TMAO plays a role in protection of the cardiomyocytes against pressure overload in patients with AS. The primary aim of this study is to assess the correlation between the serum and urine TMAO concentration, and (i) echocardiographic, (ii) biochemical and (iii) histopathological parameters of heart failure in patients with severe AS. The secondary aim of this study is to evaluate a correlation between the baseline TMAO concentrations and the post-treatment clinical status, as well as the post-treatment echocardiographic and biochemical parameters.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Trimethylamine-N-oxide (TMAO) versus echocardiographic, biochemical and histopathological indices of heart failure in patients with severe aortic stenosis: Rationale and design of the prospective, observational TASTE study.
Gąsecka A, Rzepa Ł, Konwerski M, Zawadzka M, et al · · 2022 · cited 1× · PMID 35470417 · DOI 10.5603/cj.a2022.0023
Verify or expand the search:
- PubMed search for NCT04406805
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Medical University of Warsaw trials
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04406805 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University of Warsaw
- Last refreshed: 5 June 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04406805.
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