18 and older, female only, with Ovarian Cancer or Fallopian Tube Cancer. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Safety Profile of SL-172154Primary· From Day 1 to 90 days after Last Dose of SL-172154
Number of participants with treatment emergent adverse events
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
3
SL-172154 (0.3 mg/kg)
6
SL-172154 (1.0 mg/kg)
4
SL-172154 (3.0 mg/kg)
9
SL-172154 (10.0 mg/kg)
5
Maximum Tolerated Dose (MTD) of SL-172154Primary· From Day 1 to 90 days after Last Dose of SL-172154
Number of participants with dose limiting toxicities (DLTs)
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
0
SL-172154 (0.3 mg/kg)
0
SL-172154 (1.0 mg/kg)
0
SL-172154 (3.0 mg/kg)
0
SL-172154 (10.0 mg/kg)
1
Recommended Phase 2 Dose (RP2D) for SL-172154Secondary· Approximately 24 months
Based on review of all data, including safety, tolerability, PK, antitumor activity, and PD effects
Group
Value
95% CI
SL-172154
3.0
Assess Preliminary Evidence of Anti-tumor Activity of SL-172154Secondary· Approximately 24 months
Number of participants with an objective response per investigator assessment according to Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v 1.1). Objective response includes complete response (disappearance of all target lesions) and partial response (\>/= 30% decrease in the sum of the longest diameter of target lesions).
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
0
SL-172154 (0.3 mg/kg)
0
SL-172154 (1.0 mg/kg)
0
SL-172154 (3.0 mg/kg)
0
SL-172154 (10.0 mg/kg)
0
Immunogenicity to SL-172154Secondary· Approximately 24 months
Number of participants with positive anti-drug antibody (ADA) titer, sustained ADA response (positive ADA in \>/= 2 samples without reverting to negative ADA or positive ADA in the last sample), or persistent ADA response (positive ADA in \>/= 2 samples where the first and last samples are \>/= 16 weeks apart, or positive ADA in the last sample, or only one sample but \< 16 weeks before a negative last sample).
Positive anti-drug antibody titer
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
1
SL-172154 (0.3 mg/kg)
4
SL-172154 (1.0 mg/kg)
2
SL-172154 (3.0 mg/kg)
3
SL-172154 (10.0 mg/kg)
3
Sustained ADA response
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
1
SL-172154 (0.3 mg/kg)
3
SL-172154 (1.0 mg/kg)
2
SL-172154 (3.0 mg/kg)
1
SL-172154 (10.0 mg/kg)
1
Persistent ADA response
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
0
SL-172154 (0.3 mg/kg)
1
SL-172154 (1.0 mg/kg)
1
SL-172154 (3.0 mg/kg)
1
SL-172154 (10.0 mg/kg)
0
Maximum Serum Concentration (Cmax) of SL-172154Secondary· Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (each cycle = 28 days)
The Cmax is the maximum observed serum concentration of SL-172154 following single and multiple doses
Cycle 1 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
117.68
± 31.06
SL-172154 (0.3 mg/kg)
126.33
± 89.20
SL-172154 (1.0 mg/kg)
545.03
± 406.44
SL-172154 (3.0 mg/kg)
4593.19
± 90.34
SL-172154 (10.0 mg/kg)
87509.31
± 51.12
Cycle 1 Day 15
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
59.20
± 29.92
SL-172154 (0.3 mg/kg)
136.96
± 93.93
SL-172154 (1.0 mg/kg)
1772.77
± 111.10
SL-172154 (3.0 mg/kg)
3071.26
± 883.11
SL-172154 (10.0 mg/kg)
50484.31
± 33.38
Cycle 2 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
72.96
± 55.09
SL-172154 (0.3 mg/kg)
82.11
± 14.84
SL-172154 (1.0 mg/kg)
1240.25
± 72.61
SL-172154 (3.0 mg/kg)
5219.40
± 151.02
SL-172154 (10.0 mg/kg)
115536.25
± 51.83
Minimum Serum Concentration (Cmin) of SL-172154Secondary· Cycle 1 Day 15 and Cycle 2 Day 1 (each cycle = 28 days)
The Cmin is the minimum observed serum concentration of SL-172154 following at least one dose
Cycle 1 Day 15
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
0
± NA
SL-172154 (0.3 mg/kg)
0
± NA
SL-172154 (1.0 mg/kg)
0
± NA
SL-172154 (3.0 mg/kg)
0
± NA
SL-172154 (10.0 mg/kg)
0
± NA
Cycle 2 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
0
± NA
SL-172154 (0.3 mg/kg)
0
± NA
SL-172154 (1.0 mg/kg)
0
± NA
SL-172154 (3.0 mg/kg)
0
± NA
SL-172154 (10.0 mg/kg)
0
± NA
Time at Which Maximum Concentration of SL-172154 is Observed (Tmax)Secondary· Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (each cycle = 28 days)
The Tmax is the time at which the maximum concentration of SL-172154 is observed following single and multiple doses
Cycle 1 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
0.5
0.5 – 0.5
SL-172154 (0.3 mg/kg)
0.56
0.5 – 1.6
SL-172154 (1.0 mg/kg)
0.55
0.5 – 2.6
SL-172154 (3.0 mg/kg)
2.53
1.1 – 5.0
SL-172154 (10.0 mg/kg)
3.43
2.0 – 5.0
Cycle 1 Day 15
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
0.53
0.5 – 0.7
SL-172154 (0.3 mg/kg)
0.54
0.5 – 2.3
SL-172154 (1.0 mg/kg)
0.57
0.5 – 0.6
SL-172154 (3.0 mg/kg)
2.06
1.1 – 2.8
SL-172154 (10.0 mg/kg)
3.6
2.0 – 3.6
Cycle 2 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
0.5
0.5 – 0.5
SL-172154 (0.3 mg/kg)
0.53
0.5 – 1.1
SL-172154 (1.0 mg/kg)
0.55
0.5 – 1.5
SL-172154 (3.0 mg/kg)
2.08
1.0 – 4.1
SL-172154 (10.0 mg/kg)
1.97
1.9 – 2.0
Area Under the Serum Concentration-time Curve (AUC)Secondary· Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (each cycle = 28 days)
The AUC is the area under the serum concentration time curve following single and multiple doses of SL-172154. AUC (0-last; from time 0 to the last quantifiable concentration) is reported for C1D1 and AUC (tau; over a dosing interval) is reported for C1D15 and C2D1.
Cycle 1 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
143.54
± 7.74
SL-172154 (1.0 mg/kg)
639.40
± 18.47
SL-172154 (3.0 mg/kg)
7062.14
± 81.59
SL-172154 (10.0 mg/kg)
200095.11
± 78.74
Cycle 1 Day 15
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
NA
± NA
SL-172154 (1.0 mg/kg)
NA
± NA
SL-172154 (3.0 mg/kg)
13030.1
± 27.31
SL-172154 (10.0 mg/kg)
133015.0
± NA
Cycle 2 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
NA
± NA
SL-172154 (1.0 mg/kg)
NA
± NA
SL-172154 (3.0 mg/kg)
6103.60
± 130.09
SL-172154 (10.0 mg/kg)
236849.02
± 91.90
Terminal Elimination Half-life (t1/2)Secondary· Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (each cycle = 28 days)
Terminal elimination half-life (t1/2) of SL-172154
Cycle 1 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
0.50
± NA
SL-172154 (1.0 mg/kg)
0.37
± 0.056
SL-172154 (3.0 mg/kg)
0.75
± 0.710
SL-172154 (10.0 mg/kg)
0.86
± 0.278
Cycle 1 Day 15
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
NA
± NA
SL-172154 (1.0 mg/kg)
NA
± NA
SL-172154 (3.0 mg/kg)
0.32
± 0.132
SL-172154 (10.0 mg/kg)
0.71
± NA
Cycle 2 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
NA
± NA
SL-172154 (1.0 mg/kg)
NA
± NA
SL-172154 (3.0 mg/kg)
0.36
± 0.158
SL-172154 (10.0 mg/kg)
1.30
± 0.477
Clearance (CL)Secondary· Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (each cycle = 28 days)
Clearance of SL-172154
Cycle 1 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
110.64
± NA
SL-172154 (1.0 mg/kg)
121.22
± 46.305
SL-172154 (3.0 mg/kg)
35.73
± 25.580
SL-172154 (10.0 mg/kg)
4.13
± 2.605
Cycle 1 Day 15
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
NA
± NA
SL-172154 (1.0 mg/kg)
NA
± NA
SL-172154 (3.0 mg/kg)
15.15
± 2.650
SL-172154 (10.0 mg/kg)
4.44
± NA
Cycle 2 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
NA
± NA
SL-172154 (1.0 mg/kg)
NA
± NA
SL-172154 (3.0 mg/kg)
44.88
± 48.958
SL-172154 (10.0 mg/kg)
3.17
± 1.637
Volume of DistributionSecondary· Cycle 1 Day 1, Cycle 1 Day 15, and Cycle 2 Day 1 (each cycle = 28 days)
Volume of distribution of SL-172154
Cycle 1 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
79.83
± NA
SL-172154 (1.0 mg/kg)
64.28
± 28.528
SL-172154 (3.0 mg/kg)
28.46
± 17.148
SL-172154 (10.0 mg/kg)
4.84
± 2.982
Cycle 1 Day 15
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
NA
± NA
SL-172154 (1.0 mg/kg)
NA
± NA
SL-172154 (3.0 mg/kg)
7.32
± 4.187
SL-172154 (10.0 mg/kg)
4.53
± NA
Cycle 2 Day 1
Group
Value
95% CI
SL-172154 (0.1 mg/kg)
NA
± NA
SL-172154 (0.3 mg/kg)
NA
± NA
SL-172154 (1.0 mg/kg)
NA
± NA
SL-172154 (3.0 mg/kg)
32.01
± 49.282
SL-172154 (10.0 mg/kg)
5.62
± 3.337
Adverse events — posted to ClinicalTrials.gov
Time frame: Subjects were followed continuously for all AEs starting when a subject signed the informed consent form, throughout the course of treatment, and for 90 days after the last dose of study treatment, an average of 10.5 weeks..
Reporting threshold: 5%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
This is a Phase 1 first in human, open label, multi-center, dose escalation study to evaluate the safety, tolerability, PK, anti-tumor activity and pharmacodynamic effects of SL-172154 in subjects with ovarian cancer.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
NCT05275439 — Phase 1 Study of Shattuck Labs (SL)-172154 in Subjects With MDS or AML
· Phase 1
· terminated
Other recruiting trials for Ovarian Cancer
Currently open trials in the same condition.
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· Phase 4
· recruiting
NCT06930755 — Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer
· Phase 1
· recruiting
NCT07318558 — A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)
· Phase 3
· recruiting
NCT07491081 — EARLY Study: Evaluating the Specificity and Feasibility of the EARLY Biomarker Panel for Ovarian Cancer Detection
· NA
· recruiting
NCT07410676 — EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors
· Phase 1, PHASE2
· recruiting
Other Shattuck Labs, Inc. trials
Trials by the same sponsor.
NCT05483933 — Phase 1b Study of SL-172154 Administered With Combination Agent(s) in Subjects With Ovarian Cancers
· Phase 1
· completed
NCT05275439 — Phase 1 Study of Shattuck Labs (SL)-172154 in Subjects With MDS or AML
· Phase 1
· terminated
NCT04502888 — Ph1 Study of SL-172154 Administered Intratumorally in Subjects With Squamous Cell Carcinoma of the Head and Neck or Skin
· Phase 1
· terminated
NCT03894618 — SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas
· Phase 1
· completed
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shattuck Labs, Inc.
Last refreshed: 30 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04406623.