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Effect of Gut Microbiome Restoration on Primary Hypertension Via FMT
Mounting preclinical and clinical evidences have proved the causal role of gut microbiota on the pathogenesis of primary hypertension. Restoration of gut microbiota ameliorated high BP in rodents and/or human cases.A hypothesis is thus raised that gut microbiome restoration can be a potential approach to ameliorate hypertension. This pilot study will utilize fecal microbiota transplantation (FMT) capsules, in comparison with placebo capsules, to investigate the effect, safety and underlying mechanisms of gut microbiome restoration on primary hypertension.
Details
| Lead sponsor | Chinese Academy of Medical Sciences, Fuwai Hospital |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | UNKNOWN |
| Enrolment | 120 |
| Start date | Wed Mar 17 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Thu Sep 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Hypertension
Interventions
- FMT capsules
- Placebo capsules
Countries
China