Last reviewed · How we verify
NCT04406051: annie-manos
Prevention of Maternal Hypotension During Cesarean Section With Norepinephrine Infusion.
NA trial testing norepinephrine infusion and colloid preloading (NOR-COL) in Hypotension in 100 participants. Completed in 30 April 2021.
30 April 2021
Quick facts
| Lead sponsor | Aretaieion University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 100 |
| Start date | 26 May 2020 |
| Primary completion | 30 April 2021 |
| Estimated completion | 30 April 2021 |
| Sites | 2 locations across Greece |
Drugs / interventions tested
- norepinephrine infusion and colloid preloading (NOR-COL)
- norepinephrine infusion and crystalloid co-loading (NOR-CRYST)
Conditions studied
- Hypotension — all drugs for Hypotension →
- Obstetric Anesthesia Problems — all drugs for Obstetric Anesthesia Problems →
- Cesarean Section Complications — all drugs for Cesarean Section Complications →
- Hypotensive — all drugs for Hypotensive →
Sponsor
Aretaieion University Hospital
Who can join
Adults 18 to 48, female only, with Hypotension or Obstetric Anesthesia Problems. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This will be a randomized study aiming at investigating the combination of a norepinephrine infusion and colloid preloading versus the combination of a norepinephrine infusion and crystalloid co-loading for the prevention of maternal hypotension during elective cesarean section
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Colloid Preload versus Crystalloid Co-Load in the Setting of Norepinephrine Infusion during Cesarean Section: Time and Type of Administered Fluids Do Not Matter.
Theodoraki K, Hadzilia S, Valsamidis D, Kalopita K, et al · · 2023 · cited 9× · PMID 36835869 · DOI 10.3390/jcm12041333
Verify or expand the search:
- PubMed search for NCT04406051
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Hypotension
Currently open trials in the same condition.
- NCT07499947 — Predicting Spinal Hypotension in Cesarean Section · recruiting
- NCT07494955 — "Effect of Pre-Spinal Mindfulness-Based Breathing Exercise on Hemodynamic Response in Elective Cesarean Section" · NA · recruiting
- NCT07481851 — Skin Conductance for Predicting Spinal Anesthesia-Induced Hypotension in Geriatric Urologic Oncology Patients · recruiting
- NCT06994494 — Noninvasive Continuous BP Monitoring in Newborns Based on Pulsatile Signal Morphological Features Using NIRS · recruiting
- NCT06953193 — Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia · NA · recruiting
Other Aretaieion University Hospital trials
Trials by the same sponsor.
- NCT07289321 — Tramadol / Magnesium in Ropivacaine Solution in UG-bilateral TAP Block and Analgesia in Robotic Radical Prostatectomy · NA · enrolling by invitation
- NCT06464393 — Opioid-based Versus Opioid-free Endotracheal Intubation · NA · completed
- NCT06376058 — Chloroprocaine 1% Versus Ropivacaine 0,75% During Cesarean Section · NA · recruiting
- NCT04718116 — Tapentadol Versus Tramadol Analgesia Post Cardiac Surgery · NA · unknown
- NCT05567822 — The Impact of Esmolol Administration on Postoperative Recovery · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04406051 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Aretaieion University Hospital
- Last refreshed: 15 June 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04406051.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing