NCT04405388 (SMARTEST) is a Phase 3 clinical trial of Spermidine in Hypertension, sponsored by Medical University of Graz.

Who is sponsoring NCT04405388?

NCT04405388 is sponsored by Medical University of Graz.

What drugs are being tested in NCT04405388?

Interventions in NCT04405388: Placebo, Spermidine.

What condition does NCT04405388 study?

NCT04405388 studies Hypertension.

Is NCT04405388 still recruiting?

NCT04405388 is currently status unknown. Last updated 10 January 2023.

Last reviewed 2023-01-10 · How we verify

NCT04405388: SMARTEST

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Spermidine Anti-Hypertension Study

Status unknown Phase 3 Last updated 10 January 2023

What this trial tests

Phase 3 trial testing Placebo in Hypertension in 46 participants. Status unknown.

Timeline

25 February 2020

Primary endpoint
15 November 2024

15 November 2024

Quick facts

Lead sponsor	Medical University of Graz
Phase	Phase 3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	46
Start date	25 February 2020
Primary completion	15 November 2024
Estimated completion	15 November 2024
Sites	1 location across Austria

Drugs / interventions tested

Placebo
Spermidine — full drug profile →

Conditions studied

Hypertension — all drugs for Hypertension →

Sponsor

Medical University of Graz

Who can join

Adults 19 to 99, any sex, with Hypertension. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The impact of daily spermidine application on arterial blood pressure and other secondary parameters will be evaluated in a double-blind single center 46 patients cross-over study.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Caloric Restriction Mimetics in Nutrition and Clinical Trials.
Hofer SJ, Davinelli S, Bergmann M, Scapagnini G, et al · · 2021 · cited 76× · PMID 34552954 · DOI 10.3389/fnut.2021.717343
Effect of Cellular Senescence in Disease Progression and Transplantation: Immune Cells and Solid Organs.
Kirchner VA, Badshah JS, Hong SK, Martinez O, et al · · 2024 · cited 8× · PMID 37953486 · DOI 10.1097/tp.0000000000004838
Mitophagy in the pathogenesis and management of disease.
Wang Q, Sun Y, Li TY, Auwerx J. · · 2026 · cited 1× · PMID 41486294 · DOI 10.1038/s41422-025-01203-7
Insights into the therapeutic strategies for aging and aging-associated diseases.
Dong R, Wu Q, Kan J, Fu C, et al · · 2026 · PMID 42225652 · DOI 10.1038/s41392-026-02662-z

Verify or expand the search:

Other trials of Spermidine

Trials testing the same drug.

NCT07058974 — A Study of Exercise and Pharmacologic Intervention on Systemic Inflammation · Phase 1 · recruiting
NCT07035626 — A Randomized Controlled Trial of Spermidine for the Prevention of Radiation-Induced Xerostomia in Head and Neck Squamous · Phase 1, PHASE2 · recruiting
NCT05017428 — Absorption and Digestion Kinetics of Human Metabolites · NA · completed

Other recruiting trials for Hypertension

Currently open trials in the same condition.

NCT07413159 — The "Check, Monitor, Control Hypertension" Study is a 24-month Randomized Trial in Houston Targeting African Americans A · NA · recruiting
NCT07361276 — Observational Study That Will Evaluate Treatment Patterns in the Management of Hypertension in the Public Primary Care S · recruiting
NCT07238556 — A Novel Digital Tool Physicians Can Use to Prescribe Exercise to Patients With Cardiovascular Disease Risk Factors · NA · recruiting
NCT07238400 — Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia · Phase 2 · recruiting
NCT07135505 — Early Time-Restricted Eating in Older Adults With Hypertension · NA · recruiting

Other Medical University of Graz trials

Trials by the same sponsor.

NCT07498244 — Collagen Fingerprinting for Stratification of Pulmonary Hypertension (PH) Patients · recruiting
NCT07492823 — Clinical Applicability of Liquid Biopsy in Chondrosarcoma · not yet recruiting
NCT07297615 — 3D Liver Volumetry · NA · not yet recruiting
NCT07588282 — The Effect of Psychoeducational Diagnosis Communication on Perception of Illness, Satisfaction, and Behavioral Intention · NA · recruiting
NCT07376096 — Liquid Biopsy in Germ Cell Tumors · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04405388 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Graz
Last refreshed: 10 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04405388.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing