NCT04404868 (BTX_ST-ITA14) is a clinical trial of Normal clinical practice in Stroke, sponsored by Universita di Verona.

Who is sponsoring NCT04404868?

NCT04404868 is sponsored by Universita di Verona.

What drugs are being tested in NCT04404868?

Interventions in NCT04404868: Normal clinical practice.

Is NCT04404868 still recruiting?

NCT04404868 is currently completed. Last updated 28 May 2020.

Last reviewed 2020-05-28 · How we verify

NCT04404868: BTX_ST-ITA14

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Early Treatment of Post-stroke Spasticity With Botulinum Toxin

Completed Last updated 28 May 2020

What this trial tests

trial testing Normal clinical practice in Stroke in 86 participants. Completed in 31 December 2018.

Timeline

27 July 2015

Primary endpoint
31 December 2018

31 December 2018

Quick facts

Lead sponsor	Universita di Verona
Status	Completed
Study type	OBSERVATIONAL
Enrollment	86
Start date	27 July 2015
Primary completion	31 December 2018
Estimated completion	31 December 2018
Sites	1 location across Italy

Drugs / interventions tested

Normal clinical practice

Conditions studied

Stroke — all drugs for Stroke →

Sponsor

Universita di Verona — full company profile →

Who can join

18 and older, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This was a multicentric observational study with the aim to evaluate the effect of early treatment with botulinum toxin type A (BoNT-A) on post-stroke spasticity in adult patients. All patients enrolled (86 patients) after a baseline clinical assessment (modified Ashworth scale, motricity index, Fughl Meyer assessment and modified Rankin' scale) undergoes to a BoNT-A injection following the evidence-based clinical practice. Subsequently, at 4, 12 and 24 weeks they underwent the same clinical evaluation as a follow-up. Results are under statistical evaluation.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Early Botulinum Toxin Type A Injection for Post-Stroke Spasticity: A Longitudinal Cohort Study.
Picelli A, Santamato A, Cosma M, Baricich A, et al · · 2021 · cited 27× · PMID 34073918 · DOI 10.3390/toxins13060374
Early Botulinum Toxin Type A Injection May Improve Motor Recovery in Patients with Post-Stroke Spasticity: A Secondary Analysis from a Longitudinal Cohort Study.
Picelli A, Santamato A, Cosma M, Baricich A, et al · · 2025 · PMID 41295873 · DOI 10.3390/toxins17110558

Verify or expand the search:

Other recruiting trials for Stroke

Currently open trials in the same condition.

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NCT06704074 — Virtual Reality Task Oriented Training on Upper Limb Function in Stroke Patients · NA · recruiting

Other Universita di Verona trials

Trials by the same sponsor.

NCT07393919 — Discontination of Antidepressants in Remitted Depression · Phase 4 · not yet recruiting
NCT07042724 — Exercise and Nutrition on Early-stage NSCLC Outcomes: the STARLighT Study · NA · recruiting
NCT07129954 — Fear of Falling in Muscular Dystrophy · NA · recruiting
NCT07119827 — Personality Traits as a Variable in the Recovery of Patients With Acquired Brain Injury · recruiting
NCT07209306 — WHO Psychological Interventions for Mental Health Outcomes in Migrants Resettled in Italy: the ADVANCE Trial · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04404868 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universita di Verona
Last refreshed: 28 May 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04404868.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing