NCT04403542 is a NA clinical trial of Lehfilcon A contact lens in Refractive Errors, sponsored by Alcon Research.

Who is sponsoring NCT04403542?

NCT04403542 is sponsored by Alcon Research.

What drugs are being tested in NCT04403542?

Interventions in NCT04403542: Lehfilcon A contact lens, Comfilcon A contact lens.

What condition does NCT04403542 study?

NCT04403542 studies Refractive Errors, Myopia, Hyperopia.

Is NCT04403542 still recruiting?

NCT04403542 is currently completed. Last updated 22 August 2023.

Are results published for NCT04403542?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2023-08-22 · How we verify

NCT04403542

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pilot Clinical Performance of a Silicone Hydrogel Lens for Up to Six Nights of Extended Wear

Completed NA Results posted Last updated 22 August 2023

What this trial tests

NA trial testing Lehfilcon A contact lens in Refractive Errors in 36 participants. Completed in 31 August 2020.

Timeline

3 August 2020

Primary endpoint
31 August 2020

31 August 2020

Quick facts

Lead sponsor	Alcon Research
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	36
Start date	3 August 2020
Primary completion	31 August 2020
Estimated completion	31 August 2020
Sites	3 locations across United States

Drugs / interventions tested

Lehfilcon A contact lens
Comfilcon A contact lens

Conditions studied

Refractive Errors — all drugs for Refractive Errors →
Myopia — all drugs for Myopia →
Hyperopia — all drugs for Hyperopia →

Sponsor

Alcon Research — full company profile →

Who can join

18 and older, any sex, with Refractive Errors or Myopia. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Distance Visual Acuity (VA) With Study Lenses Primary · Day 1 Dispense; Day 2 Follow-up (within 4 hours of awakening); Week 1 Follow-up/Exit

Visual acuity (VA) was assessed for each eye individually with study lenses in place at a distance of 6 meters using a letter chart. VA was collected in Snellen and converted to logarithm minimum angle of resolution (logMAR). A logMAR value of 0 equates to 20/20 Snellen visual acuity (normal distance eyesight), with a lower logMAR value indicating better visual acuity. No formal hypothesis testing was planned.

Day 1 Dispense

Group	Value	95% CI
LID018869	-0.03	± 0.05
Biofinity	-0.04	± 0.06

Day 2 Follow-up

Group	Value	95% CI
LID018869	-0.03	± 0.05
Biofinity	-0.03	± 0.05

Week 1 Follow-up/Exit

Group	Value	95% CI
LID018869	-0.03	± 0.05
Biofinity	-0.03	± 0.05

Sponsor's own description

The purpose of this clinical study is to evaluate the on-eye performance of an investigational soft contact lens compared to a commercially available soft contact lens when worn continuously for up to 1 week.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Refractive Errors

Currently open trials in the same condition.

NCT07460557 — Morphological Characteristics of the Maxillomandibular Region in a 3D Representation and the Refractive Status of the Ey · recruiting
NCT06913491 — Efficacy of PEEK Acuity Versus ETDRS Chart for Assessment of Visual Acuity and Refractive Error · active not recruiting
NCT07001124 — Comparative Efficacy of Duochrome Test Verse +1 Blur Test in Detecting Refracting Error Across Different Ages · NA · active not recruiting
NCT06668246 — Performance of Refractometers With Self-adjusting Lenses Compared to Cycloplegia in Children (REFRALENS) · active not recruiting
NCT05458323 — Cognitive Level Enhancement Through Vision Exams and Refraction · NA · recruiting

Other Alcon Research trials

Trials by the same sponsor.

NCT06884202 — Evaluation of Delefilcon A Contact Lenses · NA · completed
NCT06784063 — Visual Performance With Clareon® Vivity® Intraocular Lenses (IOLs) · NA · completed
NCT06571656 — Evaluation of the Safety and Tolerability of Ocular Lubricants · NA · terminated
NCT06660290 — A Study to Evaluate 0.003% AR-15512 Safety and Drop Attributes · Phase 3 · completed
NCT06483113 — DAILIES TOTAL1® Soft Contact Lenses - Post-Market Clinical Follow-up Study · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04403542 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Alcon Research
Last refreshed: 22 August 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04403542.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing