NCT04403204 is a clinical trial of Immunofluorescence Imaging in Trauma Injury, sponsored by Dartmouth-Hitchcock Medical Center.

Who is sponsoring NCT04403204?

NCT04403204 is sponsored by Dartmouth-Hitchcock Medical Center.

What drugs are being tested in NCT04403204?

Interventions in NCT04403204: Immunofluorescence Imaging, DCE-MRI.

What condition does NCT04403204 study?

NCT04403204 studies Trauma Injury.

Is NCT04403204 still recruiting?

NCT04403204 is currently completed. Last updated 5 February 2026.

Last reviewed 2026-02-05 · How we verify

NCT04403204

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

ICG Fluorescence Imaging in Post-traumatic Infection

Completed Last updated 5 February 2026

What this trial tests

trial testing Immunofluorescence Imaging in Trauma Injury in 104 participants. Completed in 8 October 2025.

Timeline

14 September 2020

Primary endpoint
8 October 2025

8 October 2025

Quick facts

Lead sponsor	Dartmouth-Hitchcock Medical Center
Status	Completed
Study type	OBSERVATIONAL
Enrollment	104
Start date	14 September 2020
Primary completion	8 October 2025
Estimated completion	8 October 2025
Sites	4 locations across United States

Drugs / interventions tested

Immunofluorescence Imaging — full drug profile →
DCE-MRI

Conditions studied

Trauma Injury — all drugs for Trauma Injury →

Sponsor

Dartmouth-Hitchcock Medical Center

Who can join

18 and older, any sex, with Trauma Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The focus of this prospective observational study is to (1) establish the range and variation associated with bone/soft tissue perfusion in fracture patients, using ICG fluorescence imaging; (2) examine the relationship between perfusion and complications such as surgical site infection (SSI), persistent SSI, and fracture nonunion; (3) to determine whether the quantitative ICG fluorescence can be used to guide bony debridement in the setting of infected fracture to minimize complications.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Fluorescence-guided and molecularly-guided debridement: identifying devitalized and infected tissue in orthopaedic trauma.
Elliott JT, Henderson E, Streeter SS, Demidov V, et al · · 2023 · cited 2× · PMID 37056956 · DOI 10.1117/12.2661243

Verify or expand the search:

Other trials of Immunofluorescence Imaging

Trials testing the same drug.

NCT04416412 — ICG Fluorescence Imaging in Open Fracture Trauma Patients · active not recruiting
NCT04245111 — ICG Fluorescence Imaging in Trauma Patients · completed

Other recruiting trials for Trauma Injury

Currently open trials in the same condition.

NCT07312032 — The Effects of Footplate Stiffness on Foot Loading Within Carbon Fiber Custom Dynamic Orthoses · NA · recruiting
NCT06606119 — The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma · recruiting
NCT06070350 — Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children · Phase 3 · recruiting
NCT07072286 — RELIEVED (REgionaL anesthesIa PElVic fracturEs stuDy) Study. Regional Anesthesia (RA) Techniques for Pain Management in · recruiting
NCT05721378 — Permissive Weight Bearing in Displaced Intra-articular Calcaneal Fractures · NA · recruiting

Other Dartmouth-Hitchcock Medical Center trials

Trials by the same sponsor.

NCT07325474 — Plan and Protect: Safety Planning for Teens in Rural Emergency Departments · NA · not yet recruiting
NCT07428629 — Piloting an Insomnia Treatment in Patients With Ulcerative Colitis · NA · not yet recruiting
NCT06777511 — Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients · not yet recruiting
NCT07279116 — ABY-029 Head & Neck Trial · Phase 1 · not yet recruiting
NCT07063693 — ABY-029 Glioma Trial · Phase 1 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04403204 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Dartmouth-Hitchcock Medical Center
Last refreshed: 5 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04403204.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing